Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25113754 | 0.79 | HSP90AA1 (0.39) | ALDH1A1HTTSIGMAR1KMT2AHSP90AA1 | |
| SCHEMBL30323146 | 0.72 | SIGMAR1 (0.48) | ALDH1A1HTTSIGMAR1KMT2AHSP90AA1 | |
| SCHEMBL6552371 | 0.72 | SIGMAR1 (0.48) | ALDH1A1HTTSIGMAR1KMT2AHSP90AA1 | |
| SCHEMBL4628903 | 0.70 | KMT2A (0.55) | ALDH1A1HTTMAPK10SIGMAR1KMT2A | |
| SCHEMBL27721661 | 0.65 | LMNA (0.53) | ALDH1A1HTTSIGMAR1KMT2AMEN1 | |
| SCHEMBL3470063 | 0.65 | RGS4 (0.55) | ALDH1A1HTTMAPK10SIGMAR1KMT2A | |
| SCHEMBL15666947 | 0.64 | MAPK10 (0.47) | ALDH1A1HTTMAPK10SIGMAR1KMT2A | |
| SCHEMBL12359560 | 0.64 | KMT2A (0.50) | ALDH1A1SIGMAR1KMT2AHSP90AA1MEN1 | |
| SCHEMBL2921022 | 0.64 | SIGMAR1 (0.58) | SIGMAR1KMT2AMEN1LMNA | |
| SCHEMBL8242388 | 0.63 | KMT2A (0.52) | ALDH1A1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3421462-B1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER (US) | 2023-04-05 | — | — | EP | disclosed |