Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Carbon Monoxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CCL2 | P13500 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbon Monoxide SCHEMBL3177597 | 0.96 | HTR2A (0.36) | HTR2AHTR6CYP2D6KDM4ETP53 | |
| Carbon Monoxide SCHEMBL2512057 | 0.96 | HTR2A (0.36) | HTR2AHTR6CYP2D6KDM4ETP53 | |
| Carbon Monoxide SCHEMBL2514307 | 0.75 | HTR2A (0.45) | HTR2AHTR6CYP2D6KDM4ETP53 | |
| Carbon Monoxide SCHEMBL2512632 | 0.75 | HTR2A (0.41) | HTR2AHTR6CYP2D6KDM4ETP53 | |
| Carbon Monoxide SCHEMBL4154235 | 0.74 | HTR2A (0.39) | HTR2AHTR6CYP2D6KDM4ETP53 | |
| Carbon Monoxide SCHEMBL9159410 | 0.72 | HTR2A (0.38) | HTR2AHTR6CYP2D6KDM4ETP53 | |
| Carbon Monoxide SCHEMBL9720279 | 0.72 | HTR2A (0.38) | HTR2AHTR6CYP2D6KDM4ETP53 | |
| Bromide SCHEMBL6440191 | 0.71 | HTR2A (0.45) | HTR2AHTR6CYP2D6KDM4ETP53 | |
| Carbon Monoxide SCHEMBL2512562 | 0.71 | HTR2A (0.36) | HTR2AHTR6CYP2D6KDM4ETP53 | |
| Carbon Monoxide SCHEMBL2510002 | 0.71 | HTR2A (0.36) | HTR2AHTR6CYP2D6KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847553-B1 | METHOD FOR REMOVING METAL AND METHOD FOR PRODUCING POLYMER | NIPPON SODA CO (JP) | 2014-10-08 | — | — | EP | disclosed |
| US-8034971-B2 | Method for producing 1,2-phenylethane compound using atom transfer radical coupling reaction | NIPPON SODA CO., LTD. (JP) | 2011-10-11 | — | — | US | disclosed |
| US-7649079-B2 | Method for removing metal and method for producing polymer | NIPPON SODA CO., LTD. (JP) | 2010-01-19 | — | — | US | disclosed |
| US-20090275772-A1 | Metrod for Producing 1,2-Phenylethane Compound Using Atom Transfer Radical Coupling Reaction | NIPPON SODA CO., LTD. (JP) | 2009-11-05 | — | — | US | disclosed |
| US-7579401-B2 | Block polymer of polymethoxypolyethylene glycol monomethyl methacrylate and polystyrene; LiClO4 a lithium salt as electrolyte; living copolymerization, block polymerization; excellent thermal characteristics, physical characteristics, and ionic conductivity; secondary batteries | NIPPON SODA CO., LTD. (JP) | 2009-08-25 | — | — | US | disclosed |
| EP-1997798-A1 | METHOD FOR PRODUCING 1,2-PHENYLETHANE COMPOUND USING ATOM TRANSFER RADICAL COUPLING REACTION | Nippon Soda Co., Ltd. (JP) | 2008-12-03 | — | — | EP | disclosed |
| US-20080119635-A1 | Removing metallic ruthenium incorporated within a ruthenium complex from a polymerization system by adding a compound, in particular a nitrile, that is capable of coordinating with ruthenium via substitution of a ligand of ruthenium complex, thereby precipitating another easily removed ruthenium complex | NIPPON SODA CO., LTD. (JP) | 2008-05-22 | — | — | US | disclosed |
| EP-1847553-A1 | METHOD FOR REMOVING METAL AND METHOD FOR PRODUCING POLYMER | NIPPON SODA CO., LTD. (JP) | 2007-10-24 | — | — | EP | disclosed |
| EP-1553117-B1 | SOLID POLYMER ELECTROLYTE | NIPPON SODA CO (JP) | 2007-01-17 | — | — | EP | disclosed |
| US-20050256256-A1 | Block polymer of polymethoxypolyethylene glycol monomethyl methacrylate and polystyrene; LiClO4 a lithium salt as electrolyte; living copolymerization, block polymerization; excellent thermal characteristics, physical characteristics, and ionic conductivity; secondary batteries | NIPPON SODA CO., LTD (JP) | 2005-11-17 | — | — | US | disclosed |
| EP-1553117-A1 | SOLID POLYMER ELECTROLYTE | NIPPON SODA CO., LTD. (JP) | 2005-07-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119635-A1 | Removing metallic ruthenium incorporated within a ruthenium complex from a polymerization system by adding a compound, in particular a nitrile, that is capable of coordinating with ruthenium via substitution of a ligand of ruthenium complex, thereby precipitating another easily removed ruthenium complex | SRP54, RNF4, RPL7 | CHRM2 2222/4885CHRM1 2638/4885CHRM3 2211/4885 |
| US-20090275772-A1 | Metrod for Producing 1,2-Phenylethane Compound Using Atom Transfer Radical Coupling Reaction | ROS1, MET, MT-CO1 | CHRM2 2847/4885CHRM1 1288/4885CHRM3 2958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.