Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.45 |
| ▸ | TUBB | P07437 | 1/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23958825 | 0.84 | SMN1; SMN2 (0.51) | NPC1RAB9ASMN1; SMN2CASP3SENP8 | |
| SCHEMBL7566122 | 0.84 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2CASP3SENP8 | |
| SCHEMBL7562908 | 0.84 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2CASP3SENP8 | |
| SCHEMBL30006707 | 0.83 | SMN1; SMN2 (0.50) | NPC1RAB9ASMN1; SMN2CASP3SENP8 | |
| SCHEMBL23930037 | 0.83 | SMN1; SMN2 (0.50) | NPC1RAB9ASMN1; SMN2CASP3SENP8 | |
| SCHEMBL7569718 | 0.82 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2CASP3SENP8 | |
| SCHEMBL23958828 | 0.82 | SMN1; SMN2 (0.52) | NPC1RAB9ASMN1; SMN2CASP3SENP8 | |
| SCHEMBL25686480 | 0.81 | LMNA (0.49) | NPC1RAB9ASMN1; SMN2CASP3SENP8 | |
| SCHEMBL5264429 | 0.80 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2CASP3SENP8 | |
| SCHEMBL2579354 | 0.78 | LMNA (0.49) | NPC1RAB9ASMN1; SMN2CASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2562158-A1 | Processes for the preparation of n-heteroaryl-N-aryl-amines by reacting an N-aryl carbamic acid ester with a halo-heteroaryl and analogous processes | Vertex Pharmaceuticals Incorporated (US) | 2013-02-27 | — | — | EP | disclosed |
| EP-2562158-A1 | Processes for the preparation of n-heteroaryl-N-aryl-amines by reacting an N-aryl carbamic acid ester with a halo-heteroaryl and analogous processes | Vertex Pharmaceuticals Incorporated (US) | 2013-02-27 | — | — | EP | disclosed |
| EP-1603878-B1 | PROCESSES FOR THE PREPARATION OF N-HETEROARYL-N-ARYL-AMINES BY REACTING AN N-ARYL CARBAMIC ACID ESTER WITH A HALO-HETEROARYL AND ANALOGOUS PROCESSES | VERTEX PHARMA (US) | 2013-01-02 | — | — | EP | disclosed |
| EP-1603878-B1 | PROCESSES FOR THE PREPARATION OF N-HETEROARYL-N-ARYL-AMINES BY REACTING AN N-ARYL CARBAMIC ACID ESTER WITH A HALO-HETEROARYL AND ANALOGOUS PROCESSES | VERTEX PHARMA (US) | 2013-01-02 | — | — | EP | disclosed |
| US-20120157684-A1 | PROCESSES FOR THE FACILE SYNTHESIS OF DIARYL AMINES AND ANALOGUES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120157684-A1 | PROCESSES FOR THE FACILE SYNTHESIS OF DIARYL AMINES AND ANALOGUES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120157684-A1 | PROCESSES FOR THE FACILE SYNTHESIS OF DIARYL AMINES AND ANALOGUES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-21 | — | — | US | disclosed |
| US-8034950-B2 | Processes for the facile synthesis of diaryl amines and analogues thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-10-11 | — | — | US | disclosed |
| US-8034950-B2 | Processes for the facile synthesis of diaryl amines and analogues thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-10-11 | — | — | US | disclosed |
| US-8034950-B2 | Processes for the facile synthesis of diaryl amines and analogues thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-10-11 | — | — | US | disclosed |
| CN-101723891-A | Processes for the preparation of N-heteroaryl-N-aryl-amines by reacting an N-aryl carbamic acid ester with a halo-heteroaryl and analogous processes | VERTEX PHARMA | 2010-06-09 | — | — | CN | disclosed |
| CN-100579965-C | Process for preparing N-heteroaryl-N-arylamines by reacting N-aryl carbamates with haloheteroaryls and analogous processes | VERTEX PHARMA CO LTD | 2010-01-13 | — | — | CN | disclosed |
| US-20070173649-A1 | Processes for the facile synthesis of diaryl amines and analogues thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2007-07-26 | — | — | US | disclosed |
| US-20070173649-A1 | Processes for the facile synthesis of diaryl amines and analogues thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2007-07-26 | — | — | US | disclosed |
| US-20070173649-A1 | Processes for the facile synthesis of diaryl amines and analogues thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2007-07-26 | — | — | US | disclosed |
| US-7115746-B2 | Processes for the facile synthesis of diaryl amines and analogues thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-10-03 | — | — | US | disclosed |
| CN-1761653-A | Process for preparing N-heteroaryl-N-arylamines by reacting N-aryl carbamates with haloheteroaryls and analogous processes | VERTEX PHARMA (US) | 2006-04-19 | — | — | CN | disclosed |
| EP-1603878-A1 | PROCESSES FOR THE PREPARATION OF N-HETEROARYL-N-ARYL-AMINES BY REACTING AN N-ARYL CARBAMIC ACID ESTER WITH A HALO-HETEROARYL AND ANALOGOUS PROCESSES | Vertex Pharmaceuticals Incorporated (US) | 2005-12-14 | — | — | EP | disclosed |
| US-20040230058-A1 | Processes for the facile synthesis of diaryl amines and analogues thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2004-11-18 | — | — | US | disclosed |
| WO-2004072038-A1 | PROCESSES FOR THE PREPARATION OF N-HETEROARYL-N-ARYL-AMINES BY REACTING AN N-ARYL CARBAMIC ACID ESTER WITH A HALO-HETEROARYL AND ANALOGOUS PROCESSES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040230058-A1 | Processes for the facile synthesis of diaryl amines and analogues thereof | ABL1, PNMT, MAOA | NPC1 2399/4885RAB9A 1672/4885SMN1; SMN2 3716/4885 |
| US-20120157684-A1 | PROCESSES FOR THE FACILE SYNTHESIS OF DIARYL AMINES AND ANALOGUES THEREOF | ABL1, PNMT, MAOA | NPC1 2399/4885RAB9A 1672/4885SMN1; SMN2 3716/4885 |
| US-20070173649-A1 | Processes for the facile synthesis of diaryl amines and analogues thereof | ABL1, PNMT, MAOA | NPC1 2399/4885RAB9A 1672/4885SMN1; SMN2 3716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.