Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | ATR | Q13535 | 2/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TOP1 | P11387 | 2/20 | 0.48 |
| ▸ | TOP2A | P11388 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25138166 | 0.88 | MGLL (0.49) | FGFR1KDRPDGFRBHDAC6HDAC3 | |
| SCHEMBL25138202 | 0.87 | HDAC3 (0.56) | FGFR1KDRHDAC6HDAC3HDAC1 | |
| SCHEMBL25138167 | 0.81 | CHEK2 (0.55) | CHEK2MGLL | |
| SCHEMBL25138170 | 0.79 | SIRT2 (0.45) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL23709597 | 0.79 | RHEB (0.61) | FGFR1KDRPDGFRBHDAC6HDAC3 | |
| SCHEMBL25138059 | 0.79 | ALDH1A1 (0.71) | FGFR1KDRPDGFRBALDH1A1TOP1 | |
| SCHEMBL17468532 | 0.78 | HRH4 (0.62) | FGFR1KDRPDGFRBFGFR2FGFR3 | |
| SCHEMBL20765466 | 0.78 | ALDH1A1 (0.64) | FGFR1KDRPDGFRBCHEK2MGLL | |
| SCHEMBL25138168 | 0.78 | MEN1 (0.61) | MGLLALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL20683090 | 0.77 | HRH4 (0.57) | FGFR1KDRPDGFRBATRFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230117938-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASES, DISORDERS AND CONDITIONS INVOLVING TRINUCLEOTIDE REPEATS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230117938-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASES, DISORDERS AND CONDITIONS INVOLVING TRINUCLEOTIDE REPEATS | SMN1; SMN2, TRDMT1, HNRNPA2B1 | FGFR1 1531/4885KDR 3906/4885PDGFRB 3726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.