Tiratricol

Tiratricol

SCHEMBL25149

O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

THRATHRB

The experimentally established mechanism targets of Tiratricol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB known ✓ P10828 11/20 1.00
THRA known ✓ P10827 9/20 1.00
PCNA P12004 9/20 1.00
PPARG P37231 4/20 1.00
LMNA P02545 4/20 1.00
POLB P06746 3/20 1.00
HIF1A Q16665 3/20 1.00
RXRA P19793 2/20 1.00
ABCB11 O95342 2/20 1.00
GABRA1 P14867 2/20 1.00
GABRA2 P47869 2/20 1.00
GABRB2 P47870 2/20 1.00
HPGD P15428 2/20 1.00
SMN1; SMN2 Q16637 2/20 1.00
HSD17B10 Q99714 2/20 1.00
CYP1A2 P05177 1/20 1.00
PGR P06401 1/20 1.00
CHRM2 P08172 1/20 1.00
HTR1A P08908 1/20 1.00
ADRA2A P08913 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tiratricol SCHEMBL30161572 1.00 THRB (1.00) THRBPCNATHRAPPARGLMNA
Tiratricol SCHEMBL743426 1.00 THRB (1.00) THRBPCNATHRAPPARGLMNA
Tiratricol SCHEMBL8660328 0.99 THRB (0.97) THRBPCNATHRAPPARGLMNA
Tiratricol SCHEMBL10701956 0.99 THRB (0.97) THRBPCNATHRAPPARGLMNA
Tiratricol SCHEMBL2671904 0.99 THRB (0.97) THRBPCNATHRAPPARGLMNA
SCHEMBL18573065 0.91 THRB (0.82) THRBPCNATHRAPPARGLMNA
Tiratricol SCHEMBL5881667 0.90 THRB (0.81) THRBPCNATHRAPPARGLMNA
Tiratricol SCHEMBL21624999 0.88 THRB (0.77) THRBPCNATHRAPPARGLMNA
Tiratricol SCHEMBL9296273 0.88 THRB (0.77) THRBPCNATHRAPPARGLMNA
SCHEMBL5858371 0.87 THRB (0.78) THRBPCNATHRAPPARGLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 59097 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6434024-B1 None US claimed
US-20260053761-A1 USE OF THYROMIMETICS FOR THE TREATMENT OF CANCER UNIV OF VERMONT AND STATE AGRICULTURAL COLLEGE (US) 2026-02-26 US claimed
US-20250304916-A1 METHODS AND COMPOSITIONS FOR GENERATING VASCULAR LEPTOMENINGEAL CELLS TRAILHEAD BIOSYSTEMS INC (US) 2025-10-02 US claimed
EP-4569090-A2 METHODS AND COMPOSITIONS FOR GENERATING OLIGODENDROCYTE PROGENITOR CELLS Trailhead Biosystems Inc. (US) 2025-06-18 EP claimed
EP-4561704-A2 USE OF GLYCOGEN METABOLISM INHIBITORS FOR THE TREATMENT OF CANCER The University Of Vermont (US) 2025-06-04 EP claimed
EP-4129280-B1 TRIAC (3,3',5-TRIIODOTHYROACETIC ACID) FOR USE IN TREATING ALPHA-THALASSEMIA SHANGHAI SPH RARE DISEASE PHARMACEUTICAL CO LTD (CN) 2025-02-05 EP claimed
US-20240400672-A1 NOVEL MONOCLONAL ANTIBODIES DIRECTED AGAINST L-THYROXINE AND DIAGNOSTIC USES THEREOF F. HOFFMANN-LA ROCHE AG (CH) 2024-12-05 US claimed
CN-119055625-A Tiratricol use as ADV7 virus inhibitor 湖北工业大学 2024-12-03 CN claimed
EP-4430074-A1 NOVEL MONOCLONAL ANTIBODIES DIRECTED AGAINST L-THYROXINE AND DIAGNOSTIC USES THEREOF F. Hoffmann-La Roche AG (CH) 2024-09-18 EP claimed
US-20240263135-A1 COMPOSITIONS AND METHODS FOR IMMUNE CELL MODULATION IN ADOPTIVE IMMUNOTHERAPIES FATE THERAPEUTICS, INC. 2024-08-08 US claimed
US-3938940-A Primary control and ignition system for oil burners ROBERTSHAW CONTROLS COMPANY (US) 1976-02-17 US claimed
US-3939358-A Plural load lighting assembly energizable through two input terminals SAVEKER JAMES A 1976-02-17 US claimed
US-3937989-A Temperature discrimination apparatus MULTI-STATE DEVICES LTD. (CA) 1976-02-10 US claimed
US-3935522-A Control device for the electric fan TSAY PETER WEN TIEN 1976-01-27 US claimed
US-3935561-A Signal lamp configuration for directing high speed traffic and sequencing means therefor F. B. ELECTRONICS (US) 1976-01-27 US claimed
US-3934156-A Movement responsive control apparatus COLONIAL KINETICS, INC. (US) 1976-01-20 US claimed
US-3933140-A Capacitive discharge ignition adapter SYNCRO CORPORATION (US) 1976-01-20 US claimed
US-3932770-A Control circuit for switching triacs XEROX CORPORATION (US) 1976-01-13 US claimed
US-3932789-A Current sensing protector system for A. C. motors DETPROTECTOR, INC. (US) 1976-01-13 US claimed
US-3930783-A PRIMARY CONTROL MEANS FOR FURNACES ROBERTSHAW CONTROLS COMPANY (US) 1976-01-06 US claimed