Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tiratricol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 11/20 | 1.00 |
| ▸ | THRA known ✓ | P10827 | 9/20 | 1.00 |
| ▸ | PCNA | P12004 | 9/20 | 1.00 |
| ▸ | PPARG | P37231 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 3/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 3/20 | 1.00 |
| ▸ | RXRA | P19793 | 2/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | GABRA1 | P14867 | 2/20 | 1.00 |
| ▸ | GABRA2 | P47869 | 2/20 | 1.00 |
| ▸ | GABRB2 | P47870 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tiratricol SCHEMBL25149 | 1.00 | THRB (1.00) | THRBPCNATHRAPPARGLMNA | |
| Tiratricol SCHEMBL30161572 | 1.00 | THRB (1.00) | THRBPCNATHRAPPARGLMNA | |
| Tiratricol SCHEMBL8660328 | 0.99 | THRB (0.97) | THRBPCNATHRAPPARGLMNA | |
| Tiratricol SCHEMBL10701956 | 0.99 | THRB (0.97) | THRBPCNATHRAPPARGLMNA | |
| Tiratricol SCHEMBL2671904 | 0.99 | THRB (0.97) | THRBPCNATHRAPPARGLMNA | |
| SCHEMBL18573065 | 0.91 | THRB (0.82) | THRBPCNATHRAPPARGLMNA | |
| Tiratricol SCHEMBL5881667 | 0.90 | THRB (0.81) | THRBPCNATHRAPPARGLMNA | |
| Tiratricol SCHEMBL21624999 | 0.88 | THRB (0.77) | THRBPCNATHRAPPARGLMNA | |
| Tiratricol SCHEMBL9296273 | 0.88 | THRB (0.77) | THRBPCNATHRAPPARGLMNA | |
| SCHEMBL5858371 | 0.87 | THRB (0.78) | THRBPCNATHRAPPARGLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1114084-C | Temperature controlling method and apparatus for refrigerator using velocity control of ventilation pan and direction control of rotary blade | SAMSUNG ELECTRONICS CO LTD (KR) | 2003-07-09 | — | — | CN | claimed |
| CN-1173625-A | Temperature controlling method and apparatus for refrigerator using velocity control of ventilation pan and direction control of rotary blade | SAMSUNG ELECTRONICS CO LTD (KR) | 1998-02-18 | — | — | CN | claimed |
| CN-1061176-A | SURFACE AUTOMATIC WELDING MACHINE CIRCUIT | SHANMEN AUTOMATIZATION INDUSTR (CN) | 1992-05-20 | — | — | CN | claimed |
| EP-3548049-A1 | COMPOSITIONS AND METHODS FOR IMMUNE CELL MODULATION IN ADOPTIVE IMMUNOTHERAPIES | Fate Therapeutics, Inc. (US) | 2019-10-09 | — | — | EP | disclosed |
| EP-3405567-A1 | COMPOSITIONS AND METHODS FOR IMMUNE CELL MODULATION IN ADOPTIVE IMMUNOTHERAPIES | Fate Therapeutics, Inc. (US) | 2018-11-28 | — | — | EP | disclosed |
| EP-3405568-A1 | COMPOSITIONS AND METHODS FOR IMMUNE CELL MODULATION IN ADOPTIVE IMMUNOTHERAPIES | Fate Therapeutics, Inc. (US) | 2018-11-28 | — | — | EP | disclosed |
| WO-2018106595-A1 | COMPOSITIONS AND METHODS FOR IMMUNE CELL MODULATION IN ADOPTIVE IMMUNOTHERAPIES | FATE THERAPEUTICS, INC. (US) | 2018-06-14 | — | — | WO | disclosed |
| EP-2432298-B1 | Switching power supply device and adjustable power supply system including the same | TOSHIBA LIGHTING & TECHNOLOGY (JP) | 2017-11-01 | — | — | EP | disclosed |
| WO-2017127755-A1 | COMPOSITIONS AND METHODS FOR IMMUNE CELL MODULATION IN ADOPTIVE IMMUNOTHERAPIES | FATE THERAPEUTICS, INC. (US) | 2017-07-27 | — | — | WO | disclosed |
| WO-2017127729-A1 | COMPOSITIONS AND METHODS FOR IMMUNE CELL MODULATION IN ADOPTIVE IMMUNOTHERAPIES | FATE THERAPEUTICS, INC. (US) | 2017-07-27 | — | — | WO | disclosed |
| CN-205637705-U | Massage pond of built -in nozzle | 东辉休闲运动用品(上海)有限公司 | 2016-10-12 | — | — | CN | disclosed |
| EP-2432298-A2 | Switching power supply device and adjustable power supply system including the same | Toshiba Lighting&Technology Corporation (JP) | 2012-03-21 | — | — | EP | disclosed |
| CN-102300375-A | Light emitting diode (LED) dimming circuit applicable to silicon controlled rectifier dimmer | — | 2011-12-28 | — | — | CN | disclosed |
| CN-2748104-Y | Far infrared warm sitting therapeutic device | SHENYANG NEW GENE MEDICAL INST (CN) | 2005-12-28 | — | — | CN | disclosed |
| CN-1167097-C | Thermovoltaic power type solid-state switch | 桦晶科技股份有限公司 | 2004-09-15 | — | — | CN | disclosed |
| US-6581215-B1 | Sterilizing and air conditioning electronic urinal | TAI KUO-CHENG (TW) | 2003-06-24 | — | — | US | disclosed |
| JP-2001007690-A | CONTACTLESS SWITCH | FUJI ELECTRIC CO LTD | 2001-01-12 | — | — | JP | disclosed |
| CN-1222747-A | Thermovoltaic power type solid-state switch | XIE ZHENGXIONG (CN) | 1999-07-14 | — | — | CN | disclosed |
| CN-1061176-A | SURFACE AUTOMATIC WELDING MACHINE CIRCUIT | SHANMEN AUTOMATIZATION INDUSTR (CN) | 1992-05-20 | — | — | CN | disclosed |
| US-4310788-A | Speed control device of sewing machines | JANOME SEWING MACHINE CO., LTD. (JP) | 1982-01-12 | — | — | US | disclosed |