Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 19/20 | 0.78 |
| ▸ | THRA | P10827 | 17/20 | 0.78 |
| ▸ | PCNA | P12004 | 3/20 | 0.78 |
| ▸ | PPARG | P37231 | 2/20 | 0.78 |
| ▸ | POLB | P06746 | 2/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.78 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.78 |
| ▸ | PGR | P06401 | 1/20 | 0.78 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.78 |
| ▸ | HTR1A | P08908 | 1/20 | 0.78 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.78 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.78 |
| ▸ | AR | P10275 | 1/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.78 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.78 |
| ▸ | HPGD | P15428 | 1/20 | 0.78 |
| ▸ | RXRA | P19793 | 1/20 | 0.78 |
| ▸ | HTR2A | P28223 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tiratricol SCHEMBL30161572 | 0.87 | THRB (1.00) | THRBTHRAPCNAPPARGPOLB | |
| Tiratricol SCHEMBL743426 | 0.87 | THRB (1.00) | THRBTHRAPCNAPPARGPOLB | |
| Tiratricol SCHEMBL25149 | 0.87 | THRB (1.00) | THRBTHRAPCNAPPARGPOLB | |
| Tiratricol SCHEMBL2671904 | 0.86 | THRB (0.97) | THRBTHRAPCNAPPARGPOLB | |
| Tiratricol SCHEMBL8660328 | 0.86 | THRB (0.97) | THRBTHRAPCNAPPARGPOLB | |
| Tiratricol SCHEMBL10701956 | 0.86 | THRB (0.97) | THRBTHRAPCNAPPARGPOLB | |
| SCHEMBL5858756 | 0.83 | THRB (0.62) | THRBTHRAPCNAPPARGPOLB | |
| SCHEMBL18573065 | 0.82 | THRB (0.82) | THRBTHRAPCNAPPARGPOLB | |
| SCHEMBL5278593 | 0.81 | THRB (0.80) | THRBTHRAPPARG | |
| SCHEMBL6471716 | 0.81 | THRB (0.80) | THRBTHRAPCNAPPARGPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144909-B2 | Phenoxy substituted benzocondensed heteroaryl derivatives as thyroid receptor ligands | KARO BIO AB (SE) | 2006-12-05 | — | — | US | disclosed |
| US-20040116387-A1 | Phenoxy substituted benzocondensed heteroaryl derivatives as thyroid receptor ligands | KARO BIO AB (SE) | 2004-06-17 | — | — | US | disclosed |