SCHEMBL25149802

SCHEMBL25149802

O=C(O)c1cn2ccnc2cc1Br

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 2/20 0.36
TSHR P16473 1/20 0.36
HSD17B10 Q99714 1/20 0.36
LCK P06239 1/20 0.35
FYN P06241 1/20 0.35
APOBEC3A P31941 1/20 0.35
APOBEC3G Q9HC16 1/20 0.35
MEN1 O00255 1/20 0.35
CYP1A2 P05177 1/20 0.35
KMT2A Q03164 1/20 0.35
KDM4E B2RXH2 2/20 0.35
MAOB P27338 1/20 0.35
XDH P47989 1/20 0.34
SLC22A12 Q96S37 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA3 P07451 1/20 0.34
CA4 P22748 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22717449 0.81 KMT2A (0.38) TSHRMEN1CYP1A2KMT2AKDM4E
SCHEMBL6918010 0.80 GABRP (0.41) DYRK1AAPOBEC3AAPOBEC3GMEN1CYP1A2
SCHEMBL29229563 0.80 MAOB (0.43) DYRK1ATSHRAPOBEC3AAPOBEC3GMEN1
SCHEMBL31716869 0.77 GABRP (0.38) DYRK1AAPOBEC3AAPOBEC3GMEN1CYP1A2
SCHEMBL29229549 0.76 POLQ (0.41) HSD17B10LCKFYNKDM4ECA12
SCHEMBL23302224 0.75 MAOB (0.38) DYRK1AMEN1CYP1A2KMT2AMAOB
SCHEMBL27305869 0.74 KDM4C (0.41) APOBEC3AAPOBEC3GMEN1CYP1A2KMT2A
SCHEMBL22834495 0.73 IRAK4 (0.39) MAOBXDHNAMPT
SCHEMBL25149817 0.72 MEN1 (0.41) TSHRHSD17B10MEN1CYP1A2KMT2A
SCHEMBL20406365 0.72 L3MBTL1 (0.49) DYRK1AHSD17B10MEN1CYP1A2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240425500-A1 IMIDAZO[1,2-A]PYRIDINE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2024-12-26 US disclosed
CN-118043321-A Imidazo [1,2-a ] pyridine derivatives 先正达农作物保护股份公司 2024-05-14 CN disclosed
WO-2023061838-A1 IMIDAZO[1,2-A]PYRIDINE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2023-04-20 WO disclosed
CN-114127062-A Thiadiazolyl derivatives as inhibitors of DNA polymerase Theta 伊迪亚生物科学有限公司 2022-03-01 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240425500-A1 IMIDAZO[1,2-A]PYRIDINE DERIVATIVES IDO1, CYP1A1, CYP4Z1 DYRK1A 1859/4885TSHR 3212/4885HSD17B10 3177/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.