Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4160507 | 0.87 | MAOB (0.52) | APPMAOBMAOANPC1RAB9A | |
| SCHEMBL2512558 | 0.84 | MAOB (0.47) | MAOBMAOAMEN1KMT2ALMNA | |
| SCHEMBL2514148 | 0.84 | APP (0.49) | APPMAOBMAOANPC1RAB9A | |
| SCHEMBL2513277 | 0.83 | ALDH1A1 (0.55) | APPMAOBMAOANPC1RAB9A | |
| SCHEMBL1414014 | 0.80 | ALDH1A1 (0.53) | APPMAOBMAOANPC1RAB9A | |
| SCHEMBL2511985 | 0.78 | MAOB (0.44) | APPMAOBMAOANPC1RAB9A | |
| SCHEMBL9287591 | 0.77 | HPGD (0.50) | NPSR1CYP1A2HSP90AA1MAPTCYP2C19 | |
| SCHEMBL31487946 | 0.77 | HPGD (0.50) | NPSR1CYP1A2HSP90AA1MAPTCYP2C19 | |
| SCHEMBL1414062 | 0.76 | HTR1A (0.55) | MAOBMAOANPC1RAB9ATDP1 | |
| SCHEMBL1413931 | 0.74 | MAPT (0.56) | TDP1MEN1KMT2ANPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034945-B2 | 4-phenyl-5-OXO-1,4,5,6,7,8-hexahydroquinoline derivatives as medicaments for the treatment of infertility | N.V. ORGANON (NL) | 2011-10-11 | — | — | US | disclosed |
| EP-1879580-B1 | 4-PHENYL-5-OXO-1,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY | ORGANON NV (NL) | 2009-03-11 | — | — | EP | disclosed |
| US-20080300270-A1 | 4-Phenyl-5-Oxo-1,4,5,6,7,8,- Hexahydroquinoline Derivatives as Medicaments for the Treatment of Infertility | MERCK SHARP & DOHME B.V. (NL) | 2008-12-04 | — | — | US | disclosed |
| EP-1879580-A1 | 4-PHENYL-5-OXO-1,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY | N.V. Organon (NL) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006117370-A1 | 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY | N.V. ORGANON (NL) | 2006-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300270-A1 | 4-Phenyl-5-Oxo-1,4,5,6,7,8,- Hexahydroquinoline Derivatives as Medicaments for the Treatment of Infertility | FSHR, GNRHR, LHCGR | APP 4859/4885MAOB 2207/4885MAOA 1613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.