Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | RARA | P10276 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2566879 | 0.98 | RARB (0.55) | RARBALDH1A1MEN1KMT2ARARA | |
| SCHEMBL28111983 | 0.95 | RARB (0.51) | RARBALDH1A1MEN1KMT2ARARA | |
| SCHEMBL2513768 | 0.85 | GPR84 (0.44) | RARBALDH1A1MEN1KMT2ARARA | |
| SCHEMBL2530451 | 0.85 | GPR84 (0.44) | RARBALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL30281282 | 0.80 | CYP2C9 (0.61) | ALDH1A1MEN1KMT2AMAPTNPC1 | |
| SCHEMBL27782228 | 0.80 | GPR84 (0.61) | RARBALDH1A1MEN1KMT2ARARA | |
| SCHEMBL846393 | 0.80 | CYP2C9 (0.61) | ALDH1A1MEN1KMT2AMAPTNPC1 | |
| SCHEMBL8413501 | 0.80 | RARB (0.61) | RARBALDH1A1MEN1KMT2ARARA | |
| Hydrochloric Acid SCHEMBL20719501 | 0.80 | KDM4E (0.49) | ALDH1A1MEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL27733869 | 0.80 | TDP1 (0.59) | ALDH1A1TDP1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE41008-E1 | catalytic hydrogenation 5-arylnicotinic acids in presence of a palladium/ligand complex; intermediates for making N-alkylated amine; for crop protection, such as, fungicides, insecticides, herbicides or pesticides and drugs | MERCK PATENT GMBH (DE) | 2009-11-24 | — | — | US | claimed |
| EP-1569907-B1 | NICOTINAMIDE-BASED KINASE INHIBITORS | YM BIOSCIENCES AUSTRALIA PTY (AU) | 2016-03-09 | — | — | EP | disclosed |
| US-8030336-B2 | Nicotinamide-based kinase inhibitors | YM BIOSCIENCES AUSTRALIA PTY LTD (AU) | 2011-10-04 | — | — | US | disclosed |
| US-RE41008-E1 | catalytic hydrogenation 5-arylnicotinic acids in presence of a palladium/ligand complex; intermediates for making N-alkylated amine; for crop protection, such as, fungicides, insecticides, herbicides or pesticides and drugs | MERCK PATENT GMBH (DE) | 2009-11-24 | — | — | US | disclosed |
| EP-1569907-A4 | NICOTINAMIDE-BASED KINASE INHIBITORS | CYTOPIA PTY LTD (AU) | 2007-10-31 | — | — | EP | disclosed |
| WO-2007062459-A1 | SELECTIVE KINASE INHIBITORS BASED ON PYRIDINE SCAFFOLD | CYTOPIA RESEARCH PTY LTD (AU) | 2007-06-07 | — | — | WO | disclosed |
| US-RE39663-E1 | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes | APPLERA CORPORATION (US) | 2007-05-29 | — | — | US | disclosed |
| US-20070060619-A1 | Nicotinamide-based kinase inhibitors | CYTOPIA PTY LTD (AU) | 2007-03-15 | — | — | US | disclosed |
| EP-1569907-A1 | NICOTINAMIDE-BASED KINASE INHIBITORS | Cytopia PTY Ltd (AU) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004054977-A1 | NICOTINAMIDE-BASED KINASE INHIBITORS | CYTOPIA PTY LTD (AU) | 2004-07-01 | — | — | WO | disclosed |
| US-6670375-B2 | Particularly, 8-aza-, 8-carbo- and 8-oxo- tropanes having 6-or 7-substituents; preferred are the dopamine transporter, the serotonin transporter and the norepinephrine transporter. | ORGANIX, INC. | 2003-12-30 | — | — | US | disclosed |
| US-20030055259-A1 | Method for producing 5-aryl nicotinaldehydes | MERCK PATENT GMBH (DE) | 2003-03-20 | — | — | US | disclosed |
| EP-1196640-A2 | ELECTRON-DEFICIENT NITROGEN HETEROCYCLE-SUBSTITUTED FLUORESCEIN DYES | Applera Corporation (US) | 2002-04-17 | — | — | EP | disclosed |
| US-20020010207-A1 | Tropane analogs and methods for inhibition of monoamine transport | WILMINGTON TRUST (LONDON) LIMITED, AS SECURITY AGENT (GB) | 2002-01-24 | — | — | US | disclosed |
| WO-2001057264-A2 | ELECTRON-DEFICIENT NITROGEN HETEROCYCLE-SUBSTITUTED FLUORESCEIN DYES | APPLERA CORPORATION (US) | 2001-08-09 | — | — | WO | disclosed |
| US-6221604-B1 | CONJUGATED TO SUBSTRATES SUCH AS NUCLEOSIDES OR NUCLEOTIDES AND USED AS DETECTION LABELS IN MOLECULAR BIOLOGY EXPERIMENTS; ENERGY TRANSFER DYE | PE CORPORATION | 2001-04-24 | — | — | US | disclosed |
| US-5254776-A | Synthesis of bromobiphenyls | MALLINCKRODT SPECIALTY CHEMICALS COMPANY (US) | 1993-10-19 | — | — | US | disclosed |
| US-5145930-A | Star polymers | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-09-08 | — | — | US | disclosed |
| US-5070183-A | Hyperbranched polyarylene | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-12-03 | — | — | US | disclosed |
| US-4857630-A | Hyperbranched polyarylene | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060619-A1 | Nicotinamide-based kinase inhibitors | NADK, NAMPT, PDXK | RARB 1003/4885ALDH1A1 1092/4885MEN1 1147/4885 |
| US-20030055259-A1 | Method for producing 5-aryl nicotinaldehydes | NAPRT, NOX5, NNT | RARB 865/4885ALDH1A1 101/4885MEN1 1570/4885 |
| US-20020010207-A1 | Tropane analogs and methods for inhibition of monoamine transport | SLC6A2, SLC6A4, SLC6A3 | RARB 2695/4885ALDH1A1 614/4885MEN1 4140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.