Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | DNM2 | P50570 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16608746 | 0.88 | LMNA (0.50) | MAPTKMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL8349354 | 0.83 | KMT2A (0.58) | MAPTKMT2ALMNAMAPK1KDM4E | |
| SCHEMBL12499637 | 0.81 | NOS3 (0.58) | NOS3NOS2MAPTLMNAHTT | |
| SCHEMBL7865350 | 0.74 | KMT2A (0.50) | MAPTKMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL8349356 | 0.74 | KMT2A (0.54) | MAPTKMT2ALMNASMN1; SMN2MAPK1 | |
| SCHEMBL1898299 | 0.74 | LMNA (0.70) | KMT2ALMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL16608745 | 0.73 | DNM2 (0.61) | MAPTKMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL12411159 | 0.73 | NOS3 (0.48) | NOS3NOS2KMT2ALMNAHTT | |
| SCHEMBL12895816 | 0.72 | HTT (0.64) | MAPTKMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL18289310 | 0.72 | DNM2 (0.46) | MAPTKMT2ALMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023064586-A1 | NOVEL MODULATORS OF EHMT1 AND EHMT2 AND THERAPEUTIC USE THEREOF | TANGO THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |