SCHEMBL25167692

SCHEMBL25167692

Clc1cnnc2c(Br)csc12

nearest known ligand 0.31

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
GPR35 Q9HC97 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30433615 1.00 GPR35 (0.31) GPR35
SCHEMBL25167501 0.78 PDPK1 (0.36)
SCHEMBL30401622 0.76 GPR35 (0.31) GPR35
SCHEMBL25169268 0.76 GPR35 (0.31) GPR35
SCHEMBL25175097 0.74 PDE4B (0.32)
SCHEMBL14830510 0.68 EPHB4 (0.32) GPR35
SCHEMBL22346635 0.68 GPR35 (0.31) GPR35
SCHEMBL25168095 0.67
SCHEMBL31373103 0.67 PDPK1 (0.36) GPR35
SCHEMBL20443615 0.63 ALDH1A1 (0.40)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250340564-A1 COMPOSITIONS USEFUL FOR MODULATING SPLICING SKYHAWK THERAPEUTICS INC (US) 2025-11-06 US disclosed
US-20250101034-A1 COMPOSITIONS USEFUL FOR MODULATING SPLICING SKYHAWK THERAPEUTICS, INC. 2025-03-27 US disclosed
EP-4426704-A1 CONDENSED PYRIDAZINE AMINE DERIVATIVES TREATING SCA3 Skyhawk Therapeutics, Inc. (US) 2024-09-11 EP disclosed
WO-2023081857-A1 CONDENSED PYRIDAZINE AMINE DERIVATIVES TREATING SCA3 SKYHAWK THERAPEUTICS, INC. (US) 2023-05-11 WO disclosed
WO-2023081857-A1 CONDENSED PYRIDAZINE AMINE DERIVATIVES TREATING SCA3 SKYHAWK THERAPEUTICS, INC. (US) 2023-05-11 WO disclosed
WO-2023081858-A1 CONDENSED-PYRAZINE AMINE DERIVATIVES FOR TREATING SCA3 SKYHAWK THERAPEUTICS, INC. (US) 2023-05-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250101034-A1 COMPOSITIONS USEFUL FOR MODULATING SPLICING RBM17, SNRPE, SNRPA1 GPR35 4208/4885
US-20250340564-A1 COMPOSITIONS USEFUL FOR MODULATING SPLICING RBM17, SNRPE, SNRPA1 GPR35 4208/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.