Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 13/20 | 0.60 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412651 | 0.84 | NOTUM (0.63) | NOTUMPDK2SERPINE1S1PR1 | |
| SCHEMBL14332344 | 0.80 | NOTUM (0.47) | NOTUMPDK2 | |
| SCHEMBL5724958 | 0.80 | NOTUM (0.60) | NOTUM | |
| SCHEMBL1817248 | 0.80 | NOTUM (0.60) | NOTUMPDK2SERPINE1S1PR1 | |
| SCHEMBL12875602 | 0.79 | AR (0.48) | NOTUMPDK2 | |
| SCHEMBL25209622 | 0.79 | NOTUM (0.59) | NOTUMPDK2SERPINE1 | |
| SCHEMBL12875600 | 0.77 | MGLL (0.44) | NOTUMPDK2HSD11B1 | |
| SCHEMBL2071701 | 0.75 | NOTUM (0.83) | NOTUMPDK2SERPINE1 | |
| SCHEMBL6204089 | 0.75 | ALDH1A1 (0.61) | NOTUMS1PR1 | |
| SCHEMBL11888878 | 0.74 | KDM4E (0.50) | NOTUMSERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081661-A1 | BICYCLIC DERIVATIVES AS CCR2 MODULATORS | ARIA PHARMACEUTICALS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |