Phosphonodifluoromethyl Phenylalanine

Phosphonodifluoromethyl Phenylalanine

SCHEMBL2517440

N[C@@H](Cc1ccc(C(F)(F)P(=O)(O)O)cc1)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 12/20 1.00
GRB2 P62993 1/20 0.66
SLC7A5 Q01650 2/20 0.57
ALPI P09923 1/20 0.57
PKM P14618 1/20 0.57
PTGS1 P23219 1/20 0.57
XIAP P98170 1/20 0.57
PTPN2 P17706 4/20 0.55
PTPN6 P29350 4/20 0.55
PTPN11 Q06124 3/20 0.55
PGK1 P00558 2/20 0.55
PGK2 P07205 2/20 0.55
PTPRC P08575 2/20 0.55
PTPN5 P54829 1/20 0.50
PTPRB P23467 1/20 0.50
CDC25A P30304 1/20 0.50
PTPRA P18433 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phosphonodifluoromethyl Phenylalanine SCHEMBL2517439 1.00 PTPN1 (1.00) PTPN1GRB2SLC7A5ALPIPKM
Phosphonodifluoromethyl Phenylalanine SCHEMBL9545904 1.00 PTPN1 (1.00) PTPN1GRB2SLC7A5ALPIPKM
SCHEMBL27715838 0.88 PTPN1 (0.78) PTPN1GRB2PTPN2PTPN6PTPN11
SCHEMBL13997109 0.87 PTPN1 (0.76) PTPN1GRB2SLC7A5ALPIPKM
SCHEMBL7831965 0.86 PTPN1 (0.75) PTPN1PTPN2PTPN6PTPN11PGK1
SCHEMBL43861 0.82 GRB2 (0.76) PTPN1GRB2SLC7A5ALPIPKM
SCHEMBL148122 0.82 GRB2 (0.76) PTPN1GRB2SLC7A5ALPIPKM
SCHEMBL43862 0.82 GRB2 (0.76) PTPN1GRB2SLC7A5ALPIPKM
Dl-Phenylalanine SCHEMBL28313877 0.81 SLC7A5 (0.71) PTPN1GRB2SLC7A5ALPIPKM
SCHEMBL2423462 0.81 PTPN1 (0.67) PTPN1GRB2SLC7A5ALPIPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 143 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4204433-A1 INTERFERENCE PEPTIDES AS INHIBITORS OF INTERACTIONS RELATED TO AMPAR ENDOCYTOSIS Szedlacsek, Stefan Eugen (RO) 2023-07-05 EP claimed
WO-2022043969-A1 INTERFERENCE PEPTIDES AS INHIBITORS OF INTERACTIONS RELATED TO AMPAR ENDOCYTOSIS SZEDLACSEK STEFAN EUGEN (RO) 2022-03-03 WO claimed
EP-0941232-A1 LIGANDS FOR PHOSPHATASE BINDING ASSAY MERCK FROSST CANADA INC. (CA) 1999-09-15 EP claimed
WO-1998020024-A1 LIGANDS FOR PHOSPHATASE BINDING ASSAY MERCK FROSST CANADA & CO. (CA) 1998-05-14 WO claimed
WO-1993025561-A1 PHOSPHONOALKYL PHENYLALANINE COMPOUNDS SUITABLY PROTECTED FOR USE IN PEPTIDE SYNTHESIS THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1993-12-23 WO claimed
US-20260146063-A1 CYCLIC CELL PENETRATING PEPTIDES AND METHODS OF MAKING AND USING THEREOF OHIO STATE INNOVATION FOUNDATION (US) 2026-05-28 US disclosed
US-20260125426-A1 CYCLIC CELL-PENETRATING PEPTIDES AND USES THEREOF OHIO STATE INNOVATION FOUNDATION (US) 2026-05-07 US disclosed
EP-4717776-A2 POLYPEPTIDE CONJUGATES FOR INTRACELLULAR DELIVERY OF NUCLEIC ACIDS Ohio State Innovation Foundation (US) 2026-04-01 EP disclosed
US-20260070948-A1 CYCLIC CELL-PENETRATING PEPTIDES WITH CARGO OHIO STATE INNOVATION FOUNDATION (US) 2026-03-12 US disclosed
US-20260070947-A1 CYCLIC CELL-PENETRATING PEPTIDE COMPOUNDS OHIO STATE INNOVATION FOUNDATION (US) 2026-03-12 US disclosed
EP-4706689-A2 COMPOSITIONS FOR DELIVERY OF ANTISENSE COMPOUNDS Entrada Therapeutics, Inc. (US) 2026-03-11 EP disclosed
US-20260008816-A1 CYCLIC CELL PENETRATING PEPTIDES AND METHODS OF MAKING AND USING THEREOF OHIO STATE INNOVATION FOUNDATION (US) 2026-01-08 US disclosed
EP-0941232-A1 LIGANDS FOR PHOSPHATASE BINDING ASSAY MERCK FROSST CANADA INC. (CA) 1999-09-15 EP disclosed
EP-0937157-A1 HYDROLASE BINDING ASSAY Merck Frosst Canada & Co. (CA) 1999-08-25 EP disclosed
EP-0846127-A1 ACYLATED OLIGOPEPTIDE DERIVATIVES HAVING CELL SIGNAL INHIBITING ACTIVITY Novartis AG (CH) 1998-06-10 EP disclosed
WO-1998020156-A1 HYDROLASE BINDING ASSAY MERCK FROSST CANADA & CO. (CA) 1998-05-14 WO disclosed
WO-1998020024-A1 LIGANDS FOR PHOSPHATASE BINDING ASSAY MERCK FROSST CANADA & CO. (CA) 1998-05-14 WO disclosed
EP-0821696-A1 PEPTIDE ANTAGONISTS OF CELLULAR MITOGENESIS AND MOTOGENESIS AND THEIR THERAPEUTIC USE PHARMACIA & UPJOHN S.p.A. (IT) 1998-02-04 EP disclosed
WO-1997030079-A1 PEPTIDE ANTAGONISTS OF CELLULAR MITOGENESIS AND MOTOGENESIS AND THEIR THERAPEUTIC USE PHARMACIA & UPJOHN S.P.A. (IT) 1997-08-21 WO disclosed
WO-1997008193-A1 ACYLATED OLIGOPEPTIDE DERIVATIVES HAVING CELL SIGNAL INHIBITING ACTIVITY NOVARTIS AG (CH) 1997-03-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260008816-A1 CYCLIC CELL PENETRATING PEPTIDES AND METHODS OF MAKING AND USING THEREOF SLC3A2, SPPL2B, SLC7A1 PTPN1 4807/4885GRB2 1778/4885SLC7A5 16/4885
US-20260146063-A1 CYCLIC CELL PENETRATING PEPTIDES AND METHODS OF MAKING AND USING THEREOF VIP, SLC7A1, SLC6A15 PTPN1 4155/4885GRB2 2747/4885SLC7A5 7/4885
US-20260125426-A1 CYCLIC CELL-PENETRATING PEPTIDES AND USES THEREOF SLC7A1, TAP1, SLC7A5 PTPN1 3068/4885GRB2 3766/4885SLC7A5 3/4885
US-20260070947-A1 CYCLIC CELL-PENETRATING PEPTIDE COMPOUNDS SLC7A1, SLC38A7, SLC6A19 PTPN1 1774/4885GRB2 2053/4885SLC7A5 4/4885
US-20260070948-A1 CYCLIC CELL-PENETRATING PEPTIDES WITH CARGO SLC7A1, SLC38A7, SLC6A19 PTPN1 3098/4885GRB2 1913/4885SLC7A5 13/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.