Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.33 |
| ▸ | CHKA | P35790 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 3/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | STK38 | Q15208 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL252523 | 0.93 | PIK3CD (0.41) | BRD4KCNH2PDE4APIK3CDPIK3CG | |
| SCHEMBL251083 | 0.90 | CSNK1D (0.37) | GSK3BMAPK14 | |
| SCHEMBL252762 | 0.89 | JAK1 (0.39) | PIK3CDPIK3CGMETABL1GSK3B | |
| SCHEMBL253184 | 0.88 | EGLN2 (0.38) | ABL1KITGSK3BJAK1 | |
| SCHEMBL252741 | 0.87 | GSK3B (0.45) | METABL1WNT1GSK3BDYRK1A | |
| SCHEMBL253289 | 0.86 | MAPK14 (0.40) | GSK3BMAPK14 | |
| SCHEMBL252389 | 0.86 | DYRK1A (0.41) | ABL1KITWNT1GSK3BDYRK1A | |
| SCHEMBL252805 | 0.85 | KDM4E (0.40) | METABL1JAK1 | |
| SCHEMBL252772 | 0.85 | GRK5 (0.38) | PIK3CDPIK3CGABL1WNT1GSK3B | |
| SCHEMBL252203 | 0.85 | JAK2 (0.42) | PIK3CGGSK3BJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588107-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | Takeda Pharmaceutical Company Limited (JP) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003338-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-05 | — | — | WO | disclosed |