Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 18/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 18/20 | 0.45 |
| ▸ | WNT1 | P04628 | 15/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL251083 | 0.89 | CSNK1D (0.37) | GSK3B | |
| SCHEMBL252389 | 0.88 | DYRK1A (0.41) | GSK3BDYRK1AWNT1ABL1DYRK1B | |
| SCHEMBL252762 | 0.88 | JAK1 (0.39) | GSK3BABL1CLK1MET | |
| SCHEMBL251824 | 0.87 | BRD4 (0.34) | GSK3BDYRK1AWNT1ABL1MET | |
| SCHEMBL253289 | 0.87 | MAPK14 (0.40) | GSK3B | |
| SCHEMBL253184 | 0.87 | EGLN2 (0.38) | GSK3BABL1 | |
| SCHEMBL252772 | 0.86 | GRK5 (0.38) | GSK3BDYRK1AWNT1ABL1 | |
| SCHEMBL252805 | 0.86 | KDM4E (0.40) | ABL1MET | |
| SCHEMBL252203 | 0.86 | JAK2 (0.42) | GSK3B | |
| SCHEMBL252523 | 0.85 | PIK3CD (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588107-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | Takeda Pharmaceutical Company Limited (JP) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003338-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-05 | — | — | WO | disclosed |