Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 8/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 8/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL253289 | 0.93 | MAPK14 (0.40) | CSNK1DCSNK1EMAPK14GSK3BRIPK1 | |
| SCHEMBL252762 | 0.91 | JAK1 (0.39) | GSK3BSYK | |
| SCHEMBL251824 | 0.90 | BRD4 (0.34) | MAPK14GSK3B | |
| SCHEMBL253184 | 0.90 | EGLN2 (0.38) | GSK3B | |
| SCHEMBL252741 | 0.89 | GSK3B (0.45) | GSK3B | |
| SCHEMBL250931 | 0.89 | EGLN2 (0.42) | — | |
| SCHEMBL251899 | 0.89 | ABL1 (0.36) | — | |
| SCHEMBL252389 | 0.88 | DYRK1A (0.41) | GSK3B | |
| SCHEMBL252805 | 0.87 | KDM4E (0.40) | SYK | |
| SCHEMBL252772 | 0.87 | GRK5 (0.38) | MAPK14GSK3BSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588107-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | Takeda Pharmaceutical Company Limited (JP) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003338-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-05 | — | — | WO | disclosed |