Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK5 | P34947 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 9/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL253289 | 0.90 | MAPK14 (0.40) | SYKJAK2JAK3GSK3BMAPK14 | |
| SCHEMBL252203 | 0.88 | JAK2 (0.42) | SYKPIK3CGJAK2KDM4EHSD17B10 | |
| SCHEMBL252523 | 0.88 | PIK3CD (0.41) | SYKPIK3CDPIK3CGJAK2MAPK14 | |
| SCHEMBL253702 | 0.88 | SYK (0.39) | ABL1SYKPIK3CDPIK3CGJAK2 | |
| SCHEMBL251083 | 0.87 | CSNK1D (0.37) | SYKGSK3BMAPK14 | |
| SCHEMBL252762 | 0.86 | JAK1 (0.39) | ABL1SYKPIK3CDPIK3CGJAK2 | |
| SCHEMBL252741 | 0.86 | GSK3B (0.45) | ABL1WNT1GSK3BDYRK1A | |
| SCHEMBL251824 | 0.85 | BRD4 (0.34) | ABL1PIK3CDPIK3CGWNT1GSK3B | |
| SCHEMBL253184 | 0.85 | EGLN2 (0.38) | ABL1KDM4EGSK3BJAK1 | |
| SCHEMBL252389 | 0.84 | DYRK1A (0.41) | ABL1JAK2KDM4EHSD17B10WNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588107-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | Takeda Pharmaceutical Company Limited (JP) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003338-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-05 | — | — | WO | disclosed |