Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.41 |
| ▸ | WNT1 | P04628 | 4/20 | 0.41 |
| ▸ | GSK3B | P49841 | 4/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL252741 | 0.88 | GSK3B (0.45) | DYRK1AWNT1GSK3BABL1DYRK1B | |
| SCHEMBL252762 | 0.88 | JAK1 (0.39) | GSK3BJAK1TYK2KDM4EHSD17B10 | |
| SCHEMBL251083 | 0.88 | CSNK1D (0.37) | GSK3B | |
| SCHEMBL252203 | 0.86 | JAK2 (0.42) | GSK3BJAK1TYK2KDM4EHSD17B10 | |
| SCHEMBL252805 | 0.86 | KDM4E (0.40) | JAK1KDM4EHSD17B10ABL1 | |
| SCHEMBL251824 | 0.86 | BRD4 (0.34) | DYRK1AWNT1GSK3BJAK1KIT | |
| SCHEMBL253289 | 0.86 | MAPK14 (0.40) | GSK3BJAK2 | |
| SCHEMBL253184 | 0.86 | EGLN2 (0.38) | GSK3BJAK1KITKDM4EABL1 | |
| SCHEMBL252772 | 0.84 | GRK5 (0.38) | DYRK1AWNT1GSK3BJAK1KDM4E | |
| SCHEMBL253702 | 0.84 | SYK (0.39) | GSK3BJAK1JAK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588107-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | Takeda Pharmaceutical Company Limited (JP) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003338-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-05 | — | — | WO | disclosed |