Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 10/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL250931 | 0.94 | EGLN2 (0.42) | ABL1EGLN2TBK1PDE4BPDE4D | |
| SCHEMBL253184 | 0.90 | EGLN2 (0.38) | ABL1EGLN2TBK1 | |
| SCHEMBL251083 | 0.89 | CSNK1D (0.37) | — | |
| SCHEMBL253702 | 0.88 | SYK (0.39) | ABL1EGLN2RORCPDE4D | |
| SCHEMBL253289 | 0.87 | MAPK14 (0.40) | — | |
| SCHEMBL252762 | 0.84 | JAK1 (0.39) | ABL1 | |
| SCHEMBL252741 | 0.84 | GSK3B (0.45) | ABL1 | |
| SCHEMBL251824 | 0.84 | BRD4 (0.34) | ABL1 | |
| SCHEMBL252389 | 0.83 | DYRK1A (0.41) | ABL1 | |
| SCHEMBL251901 | 0.83 | CSNK1D (0.43) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588107-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | Takeda Pharmaceutical Company Limited (JP) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003338-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-05 | — | — | WO | disclosed |