SCHEMBL25201412

SCHEMBL25201412

COc1nc(N[C@H](C)C(F)(F)F)c2c(I)cn(S(=O)(=O)c3ccc(C)cc3)c2n1

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.32
MAPT P10636 2/20 0.31
ALDH1A1 P00352 2/20 0.31
GAA P10253 1/20 0.31
HPGD P15428 1/20 0.31
ALOX12 P18054 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
POLB P06746 1/20 0.31
ALDH3A1 P30838 1/20 0.31
HTT P42858 1/20 0.31
NOD1 Q9Y239 1/20 0.31
TSHR P16473 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
PIM1 P11309 1/20 0.30
PIM2 Q9P1W9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25266043 1.00 L3MBTL1 (0.32) L3MBTL1MAPTALDH1A1GAAHPGD
SCHEMBL30349514 1.00 L3MBTL1 (0.32) L3MBTL1MAPTALDH1A1GAAHPGD
SCHEMBL25523142 0.87 ALDH1A1 (0.33) L3MBTL1MAPTALDH1A1GAAHPGD
SCHEMBL30349201 0.77 CDK9 (0.36)
SCHEMBL25265684 0.77 CDK9 (0.36)
SCHEMBL25158098 0.77 CDK9 (0.36)
SCHEMBL25523138 0.76 MAPK14 (0.35) ALDH1A1HPGDHTTPIM1PIM2
SCHEMBL1016690 0.71 YTHDC1 (0.41) L3MBTL1MAPTALDH1A1HPGDTDP1
SCHEMBL31052310 0.69 MEN1 (0.41) L3MBTL1MAPTALDH1A1GAAHPGD
SCHEMBL30349320 0.69 SMN1; SMN2 (0.38) L3MBTL1MAPTALDH1A1GAAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250129104-A1 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AND USES THEREOF TENARX, INC. 2025-04-24 US disclosed
US-20230167133-A1 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AND USES THEREOF VICKERS VENTURE FUND VI PTE. LTD. (SG) 2023-06-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230167133-A1 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AND USES THEREOF DYRK1A, DYRK1B, DYRK2 L3MBTL1 2548/4885MAPT 341/4885ALDH1A1 3447/4885
US-20250129104-A1 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AND USES THEREOF DYRK1A, DYRK1B, DYRK2 L3MBTL1 2548/4885MAPT 341/4885ALDH1A1 3447/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.