Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25211019 | 0.79 | KDR (0.40) | MAPTGAAABL1ALOX15NPC1 | |
| SCHEMBL29598523 | 0.76 | NOS3 (0.57) | ROCK1GRM4MAP4K4 | |
| SCHEMBL30001628 | 0.76 | NOS3 (0.57) | ROCK1GSK3ARIOK2 | |
| SCHEMBL17923115 | 0.76 | NOS3 (0.57) | ROCK1GRM4MAP4K4 | |
| SCHEMBL2570584 | 0.76 | NOS3 (0.57) | ROCK1GSK3ARIOK2 | |
| Hydrochloric Acid SCHEMBL25419569 | 0.74 | NOS3 (0.55) | ROCK1GSK3ARIOK2 | |
| SCHEMBL27958617 | 0.73 | GRM4 (0.39) | ROCK1GRM4TDP1MAPTABL1 | |
| SCHEMBL25229618 | 0.73 | NOS1 (0.46) | TDP1MAPTGAATSHRNPC1 | |
| SCHEMBL22658302 | 0.73 | ROCK1 (0.42) | ROCK1TDP1MAPTGAAABL1 | |
| SCHEMBL29433388 | 0.73 | ROCK1 (0.42) | ROCK1TDP1MAPTGAAABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |