Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 8/20 | 1.00 |
| ▸ | MAOB | P27338 | 8/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.58 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25206902 | 0.79 | MAOB (1.00) | MAOAMAOBRXFP1NPSR1POLB | |
| SCHEMBL25204131 | 0.78 | MAOB (1.00) | MAOAMAOBRXFP1KMT2AMEN1 | |
| SCHEMBL21602599 | 0.76 | MAPK1 (0.68) | MAOAMAOBRXFP1KMT2ANPSR1 | |
| SCHEMBL12604457 | 0.75 | ALDH1A1 (0.63) | MAOAMAOBKMT2ANPSR1POLB | |
| SCHEMBL5113630 | 0.74 | TP53 (0.75) | MAOAMAOBRXFP1KMT2AMAPK1 | |
| SCHEMBL4146728 | 0.74 | ADORA2B (1.00) | MAOAMAOBRXFP1ADORA2AADORA2B | |
| SCHEMBL25202045 | 0.72 | POLB (0.74) | MAOAMAOBPOLBHTT | |
| SCHEMBL25210141 | 0.72 | POLB (1.00) | MAOAMAOBRXFP1KMT2APOLB | |
| SCHEMBL25208557 | 0.72 | GAA (0.81) | MAOAMAOBRXFP1POLBPKM | |
| SCHEMBL25226367 | 0.72 | POLB (0.74) | MAOAMAOBRXFP1KMT2AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11666577-B2 | MLKL inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-06-06 | — | — | US | disclosed |
| CN-110573509-B | MLKL inhibitors | 北京生命科学研究所 | 2023-05-26 | — | — | CN | disclosed |
| CN-110573509-A | MLKL inhibitors | 北京生命科学研究所 | 2019-12-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11666577-B2 | MLKL inhibitors | MLKL, CMKLR1, PCSK9 | MAOA 4584/4885MAOB 4517/4885RXFP1 1924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.