SCHEMBL25204552

SCHEMBL25204552

[CH2]c1ccc(NC(=O)[C@H](CCCCN)NC(=O)COCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCn2cc(CNC(=O)C3CCC(CN4C(=O)C=CC4=O)CC3)nn2)cc1

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ TTR P02766 1/20 0.46
▸ IL2 P60568 1/20 0.46
▸ KLKB1 P03952 3/20 0.38
▸ PLG P00747 1/20 0.36
▸ FOLH1 Q04609 3/20 0.36
▸ DGAT1 O75907 4/20 0.31
▸ F2RL1 P55085 1/20 0.31
▸ F2R P25116 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29351004 0.94 TTR (0.46) TTRIL2KLKB1PLGFOLH1
SCHEMBL20016562 0.91 TTR (0.45) TTRIL2KLKB1PLGFOLH1
SCHEMBL24335147 0.90 TTR (0.43) TTRIL2KLKB1PLGFOLH1
SCHEMBL26412265 0.89 TTR (0.42) TTRIL2KLKB1PLGFOLH1
SCHEMBL12342504 0.89 TTR (0.44) TTRIL2KLKB1PLGFOLH1
SCHEMBL25233657 0.87 TTR (0.44) TTRIL2PLGFOLH1DGAT1
SCHEMBL22969740 0.84 TTR (0.38) TTRIL2KLKB1PLGFOLH1
SCHEMBL23180460 0.83 TTR (0.37) TTRIL2KLKB1PLGFOLH1
SCHEMBL22452311 0.83 TTR (0.37) TTRIL2KLKB1PLGFOLH1
SCHEMBL24176337 0.83 TTR (0.37) TTRIL2KLKB1PLGFOLH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230270867-A1 CONJUGATE IN WHICH FL118 DRUG IS LINKED TO ACID-SENSITIVE LINKER, AND IMMUNOCONJUGATE USING SAME PINOTBIO, INC. (KR) 2023-08-31 — — US disclosed
EP-4183418-A1 CONJUGATE IN WHICH FL118 DRUG IS LINKED TO ACID-SENSITIVE LINKER, AND IMMUNOCONJUGATE USING SAME Pinotbio, Inc. (KR) 2023-05-24 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230270867-A1 CONJUGATE IN WHICH FL118 DRUG IS LINKED TO ACID-SENSITIVE LINKER, AND IMMUNOCONJUGATE USING SAME SLC46A1, SLC47A1, FOLR1 TTR 3998/4885IL2 1790/4885KLKB1 1215/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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