Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30411352 | 0.84 | HSD11B1 (0.45) | MAPTALDH1A1CCR2 | |
| SCHEMBL26629228 | 0.84 | AKR1C3 (0.37) | AKR1C3CHRNB2CHRNA4MAPTRORC | |
| SCHEMBL25229491 | 0.84 | AKR1C3 (0.37) | AKR1C3CHRNB2CHRNA4MAPTRORC | |
| SCHEMBL26677915 | 0.82 | MAPT (0.38) | MAPTALDH1A1MAPK1TDP1L3MBTL1 | |
| SCHEMBL22652110 | 0.82 | MAPT (0.38) | MAPTALDH1A1MAPK1TDP1L3MBTL1 | |
| Bicarbonate SCHEMBL30412048 | 0.82 | HSD11B1 (0.43) | MAPTALDH1A1CCR2 | |
| SCHEMBL25236239 | 0.81 | AKR1C3 (0.38) | AKR1C3RORCFAAHCCR2 | |
| SCHEMBL25241300 | 0.81 | AKR1C3 (0.38) | AKR1C3RORCFAAHCCR2 | |
| SCHEMBL25215803 | 0.81 | CHRNB2 (0.35) | AKR1C3CHRNB2CHRNA4MAPTRORC | |
| SCHEMBL26629221 | 0.81 | CHRNB2 (0.35) | AKR1C3CHRNB2CHRNA4MAPTRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023215494-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-11-09 | — | — | WO | disclosed |
| WO-2023087027-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-05-19 | — | — | WO | disclosed |