Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26629228 | 1.00 | AKR1C3 (0.37) | AKR1C3CHRNB2CHRNA4CYP19A1RORC | |
| SCHEMBL30411472 | 0.84 | HSD11B1 (0.46) | MAPT | |
| SCHEMBL30635739 | 0.84 | HSD11B1 (0.46) | MAPT | |
| SCHEMBL25208776 | 0.84 | AKR1C3 (0.35) | AKR1C3CHRNB2CHRNA4RORCGAA | |
| SCHEMBL25215803 | 0.83 | CHRNB2 (0.35) | AKR1C3CHRNB2CHRNA4RORCGAA | |
| SCHEMBL26629221 | 0.83 | CHRNB2 (0.35) | AKR1C3CHRNB2CHRNA4RORCGAA | |
| SCHEMBL22506009 | 0.82 | MAPT (0.34) | GAACASP6MAPK1MAPTPKM | |
| SCHEMBL22652198 | 0.81 | ALDH1A1 (0.36) | CYP19A1MAPK1MAPTL3MBTL1SIRT6 | |
| SCHEMBL22652044 | 0.81 | ALDH1A1 (0.36) | CYP19A1MAPK1MAPTL3MBTL1SIRT6 | |
| SCHEMBL11904967 | 0.81 | SIRT6 (0.42) | AKR1C3RORCFAAHMAPTSIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023215494-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-11-09 | — | — | WO | disclosed |
| WO-2023087027-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-05-19 | — | — | WO | disclosed |