SCHEMBL25209397

SCHEMBL25209397

O=C(O)c1ccc(C=CC(=O)c2ccc(F)cc2Br)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.59
ALDH1A1 P00352 1/20 0.59
LMNA P02545 1/20 0.59
TNFRSF1A P19438 1/20 0.54
MAOB P27338 3/20 0.52
MAPT P10636 3/20 0.52
NPSR1 Q6W5P4 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
ACHE P22303 1/20 0.52
BACE1 P56817 1/20 0.52
APP P05067 1/20 0.51
P4HB P07237 1/20 0.49
CYP3A4 P08684 1/20 0.47
ALOX15 P16050 1/20 0.47
MAPK1 P28482 1/20 0.47
BLM P54132 1/20 0.47
CASP7 P55210 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
HSD17B10 Q99714 1/20 0.47
TDP1 Q9NUW8 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25212604 1.00 TP53 (0.59) TP53ALDH1A1LMNATNFRSF1AMAOB
SCHEMBL25216445 0.86 TNFRSF1A (0.57) TP53ALDH1A1LMNATNFRSF1AMAOB
SCHEMBL25191844 0.81 APP (0.77) LMNATNFRSF1AMAOBMAPTL3MBTL1
SCHEMBL25214507 0.81 APP (0.77) LMNATNFRSF1AMAOBMAPTL3MBTL1
SCHEMBL25217889 0.80 ALDH1A1 (0.70) TP53ALDH1A1LMNATNFRSF1AMAOB
SCHEMBL25216360 0.80 ALDH1A1 (0.70) TP53ALDH1A1LMNATNFRSF1AMAOB
SCHEMBL25221701 0.79 TNFRSF1A (0.86) TP53ALDH1A1LMNATNFRSF1AMAOB
SCHEMBL1393287 0.79 TNFRSF1A (0.86) TP53ALDH1A1LMNATNFRSF1AMAOB
SCHEMBL25221345 0.79 TNFRSF1A (0.86) TP53ALDH1A1LMNATNFRSF1AMAOB
SCHEMBL1393290 0.79 TNFRSF1A (0.86) TP53ALDH1A1LMNATNFRSF1AMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B TP53 2914/4885ALDH1A1 3285/4885LMNA 1180/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 TP53 3452/4885ALDH1A1 3081/4885LMNA 1817/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 TP53 3452/4885ALDH1A1 3081/4885LMNA 1817/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.