Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRAP1 | Q12931 | 4/20 | 0.36 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.34 |
| ▸ | THRA | P10827 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30377318 | 1.00 | TRAP1 (0.36) | TRAP1HSP90B1CCNA2CDK2HSP90AA1 | |
| SCHEMBL31281890 | 0.99 | TRAP1 (0.36) | TRAP1HSP90B1CCNA2CDK2HSP90AA1 | |
| SCHEMBL31281995 | 0.95 | TRAP1 (0.38) | TRAP1HSP90B1HSP90AA1HSP90AB1SPR | |
| SCHEMBL31281933 | 0.92 | SPR (0.35) | CCNA2CDK2PARP15PARP10THRA | |
| SCHEMBL31281765 | 0.88 | TRAP1 (0.35) | TRAP1HSP90B1HSP90AA1HSP90AB1THRA | |
| SCHEMBL25599287 | 0.88 | TRAP1 (0.35) | TRAP1HSP90B1HSP90AA1HSP90AB1THRA | |
| SCHEMBL31281889 | 0.86 | TRAP1 (0.46) | TRAP1HSP90B1HSP90AA1HSP90AB1SPR | |
| SCHEMBL25599277 | 0.85 | HSP90AA1 (0.39) | TRAP1HSP90B1HSP90AA1HSP90AB1THRA | |
| SCHEMBL31281713 | 0.84 | PARP15 (0.36) | HSP90B1HSP90AA1HSP90AB1PARP15PARP10 | |
| SCHEMBL25254449 | 0.83 | NAMPT (0.35) | TRAP1HSP90B1HSP90AA1HSP90AB1THRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240425453-A1 | ISOINDOLINES AS PMS2 INHIBITORS | CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED (GB) | 2024-12-26 | — | — | US | disclosed |
| WO-2023094834-A1 | ISOINDOLINES AS PMS2 INHIBITORS | Neophore Limited (GB) | 2023-06-01 | — | — | WO | disclosed |
| WO-2023094834-A1 | ISOINDOLINES AS PMS2 INHIBITORS | Neophore Limited (GB) | 2023-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240425453-A1 | ISOINDOLINES AS PMS2 INHIBITORS | PMS2, MSH2, RECQL | TRAP1 1557/4885HSP90B1 2082/4885CCNA2 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.