SCHEMBL25210427

SCHEMBL25210427

O=C(O)NCCCCCCNc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 11/20 0.69
SMN1; SMN2 Q16637 3/20 0.69
GLA P06280 2/20 0.69
HPGD P15428 2/20 0.66
ALOX12 P18054 1/20 0.66
MAPT P10636 13/20 0.64
KDM4E B2RXH2 2/20 0.64
HTT P42858 2/20 0.53
GAA P10253 3/20 0.53
PKM P14618 1/20 0.53
MEN1 O00255 3/20 0.52
KMT2A Q03164 3/20 0.52
CYP3A4 P08684 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
HDAC3 O15379 1/20 0.49
HDAC4 P56524 1/20 0.49
HDAC1 Q13547 1/20 0.49
HDAC7 Q8WUI4 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25240545 1.00 ALDH1A1 (0.69) ALDH1A1SMN1; SMN2GLAHPGDALOX12
SCHEMBL7984789 0.89 MAPT (0.64) ALDH1A1SMN1; SMN2GLAHPGDALOX12
SCHEMBL18549022 0.87 ALDH1A1 (0.66) ALDH1A1SMN1; SMN2GLAHPGDALOX12
SCHEMBL14117517 0.87 ALDH1A1 (0.66) ALDH1A1SMN1; SMN2GLAHPGDALOX12
SCHEMBL9840107 0.85 ALDH1A1 (0.61) ALDH1A1SMN1; SMN2GLAHPGDALOX12
SCHEMBL4829828 0.85 ALDH1A1 (0.61) ALDH1A1SMN1; SMN2GLAHPGDALOX12
SCHEMBL4953010 0.83 ALDH1A1 (0.61) ALDH1A1SMN1; SMN2GLAHPGDALOX12
SCHEMBL6673456 0.83 ALDH1A1 (0.61) ALDH1A1SMN1; SMN2GLAHPGDALOX12
SCHEMBL4951837 0.82 ALDH1A1 (0.73) ALDH1A1SMN1; SMN2GLAHPGDALOX12
SCHEMBL9509667 0.81 ALDH1A1 (0.64) ALDH1A1SMN1; SMN2GLAHPGDALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023091565-A1 NSD2-TARGETED CHEMICAL DEGRADERS AND COMPOSITIONS AND METHODS OF USE THEREOF THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2023-05-25 WO disclosed