Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 6/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | GLA | P06280 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25240545 | 0.89 | ALDH1A1 (0.69) | MAPTALDH1A1KDM4EHTTMEN1 | |
| SCHEMBL25210427 | 0.89 | ALDH1A1 (0.69) | MAPTALDH1A1KDM4EHTTMEN1 | |
| SCHEMBL9003269 | 0.86 | MAPT (0.70) | MAPTALDH1A1KDM4EHTTMEN1 | |
| SCHEMBL24648 | 0.85 | MAPT (0.62) | MAPTALDH1A1KDM4EHTTMEN1 | |
| SCHEMBL14252852 | 0.85 | ALDH1A1 (0.83) | MAPTALDH1A1KDM4EHTTMEN1 | |
| SCHEMBL5623968 | 0.83 | ALDH1A1 (0.84) | MAPTALDH1A1KDM4EHTTMEN1 | |
| SCHEMBL18180862 | 0.81 | MAPT (0.84) | MAPTALDH1A1KDM4EHTTMEN1 | |
| SCHEMBL18138767 | 0.81 | MAPT (0.56) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL18138764 | 0.81 | MAPT (0.56) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL6259751 | 0.81 | ALDH1A1 (0.59) | MAPTALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001077077-A1 | SUBSTITUTED (HETERO)ARYL CARBOXAMIDE DERIVATIVES AS MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) AND APOLIPOPROTEIN B (APO B) SECRETION | NOVARTIS AG (CH) | 2001-10-18 | — | — | WO | disclosed |