Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.56 |
| ▸ | PDE4A | P27815 | 8/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.56 |
| ▸ | MAOA | P21397 | 3/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25203540 | 0.89 | PDE5A (0.56) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25204725 | 0.81 | RXFP1 (0.54) | PDE4APDE4BPDE4CPDE4DMAOA | |
| SCHEMBL25222886 | 0.81 | ADORA2A (0.54) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL21602439 | 0.77 | PDE4D (0.55) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25208007 | 0.77 | ADORA2B (0.56) | MAOAMAOBRXFP1KMT2AMEN1 | |
| SCHEMBL21602599 | 0.76 | MAPK1 (0.68) | MAOAMAOBRXFP1KMT2AMEN1 | |
| SCHEMBL25233191 | 0.74 | HPGD (0.67) | MAOAMAOBKMT2AMEN1MAPK1 | |
| SCHEMBL25227679 | 0.73 | RXFP1 (0.54) | PDE4APDE4BPDE4CPDE4DMAOA | |
| SCHEMBL25205156 | 0.73 | PKM (0.57) | PDE4APDE4BPDE4CPDE4DMAOA | |
| SCHEMBL21602516 | 0.72 | RXFP1 (0.65) | MAOAMAOBRXFP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11666577-B2 | MLKL inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-06-06 | — | — | US | disclosed |
| CN-110573509-B | MLKL inhibitors | 北京生命科学研究所 | 2023-05-26 | — | — | CN | disclosed |
| CN-110573509-A | MLKL inhibitors | 北京生命科学研究所 | 2019-12-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11666577-B2 | MLKL inhibitors | MLKL, CMKLR1, PCSK9 | PDE5A 2124/4885PDE4A 2095/4885PDE4B 1621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.