⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrrolidine SCHEMBL28160131 | 0.95 | ALDH1A1 (0.58) | — | |
| Piperidine SCHEMBL2772399 | 0.92 | ALDH1A1 (0.55) | — | |
| Piperidine SCHEMBL8573009 | 0.92 | ALDH1A1 (0.55) | — | |
| Acrylamide SCHEMBL12544993 | 0.91 | — | — | |
| Piperazine SCHEMBL8010364 | 0.88 | ALDH1A1 (0.65) | — | |
| Piperazine SCHEMBL905449 | 0.88 | ALDH1A1 (0.65) | — | |
| Cyclohexane SCHEMBL2246750 | 0.84 | ALDH1A1 (0.79) | — | |
| Cyclohexane SCHEMBL346356 | 0.84 | ALDH1A1 (0.79) | — | |
| Acrylamide SCHEMBL4784759 | 0.84 | — | — | |
| Acrylamide SCHEMBL28115160 | 0.82 | ALDH1A1 (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260083722-A1 | BIFUNCTIONAL DEGRADERS COMPRISING ELECTROPHILIC PROTACS THAT ENGAGE DCAF1 AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | SCRIPPS RESEARCH INST (US) | 2026-03-26 | — | — | US | claimed |
| WO-2023225625-A2 | BIFUNCTIONAL DEGRADERS COMPRISING ELECTROPHILIC PROTACS THAT ENGAGE DCAF1 AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-11-23 | — | — | WO | claimed |
| US-20260083722-A1 | BIFUNCTIONAL DEGRADERS COMPRISING ELECTROPHILIC PROTACS THAT ENGAGE DCAF1 AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | SCRIPPS RESEARCH INST (US) | 2026-03-26 | — | — | US | disclosed |
| WO-2025151850-A1 | SPIROCYCLE ACRYLAMIDES THAT STEREO- AND SITE-SELECTIVELY DEGRADE THE TRANSCRIPTIONAL AND DNA-DAMAGE RESPONSE PROTEIN ERCC3 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2025-07-17 | — | — | WO | disclosed |
| US-20250034216-A1 | STEREOSELECTIVE COVALENT LIGANDS FOR ONCOGENIC AND IMMUNOLOGICAL PROTEINS | THE SCRIPPS RESEARCH INSTITUTE | 2025-01-30 | — | — | US | disclosed |
| WO-2023225625-A2 | BIFUNCTIONAL DEGRADERS COMPRISING ELECTROPHILIC PROTACS THAT ENGAGE DCAF1 AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-11-23 | — | — | WO | disclosed |
| WO-2023092133-A1 | STEREOSELECTIVE COVALENT LIGANDS FOR ONCOGENIC AND IMMUNOLOGICAL PROTEINS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-05-25 | — | — | WO | disclosed |