Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL8010364 | 1.00 | ALDH1A1 (0.65) | ALDH1A1TSHRFGFR4MAPTHIF1A | |
| Acrylamide SCHEMBL12544993 | 0.97 | — | — | |
| Pyrrolidine SCHEMBL28160131 | 0.89 | ALDH1A1 (0.58) | ALDH1A1TSHRFGFR4MAPTLMNA | |
| Acrylamide SCHEMBL25213622 | 0.88 | — | — | |
| Piperidine SCHEMBL8573009 | 0.87 | ALDH1A1 (0.55) | ALDH1A1TSHRFGFR4MAPTLMNA | |
| Piperidine SCHEMBL2772399 | 0.87 | ALDH1A1 (0.55) | ALDH1A1TSHRFGFR4MAPTLMNA | |
| Acrylamide SCHEMBL4784759 | 0.84 | — | — | |
| Morpholine SCHEMBL1638456 | 0.83 | ALDH1A1 (0.50) | ALDH1A1TSHRFGFR4KDM4EKMT2A | |
| Adipic Acid SCHEMBL8010920 | 0.82 | ABCC4 (0.45) | ALDH1A1TSHRFGFR4MAPTLMNA | |
| Acrylamide SCHEMBL28115160 | 0.82 | ALDH1A1 (0.65) | ALDH1A1TSHRFGFR4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1177 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12638614-B2 | Method for making silicone hydrogel contact lenses | ALCON INC. (CH) | 2026-05-26 | — | — | US | claimed |
| EP-4304842-B1 | METHOD FOR MAKING PHOTOFUNCTIONAL CONTACT LENSES | ALCON INC (CH) | 2026-05-06 | — | — | EP | claimed |
| US-12578320-B2 | Methods and systems for physical expansion and imaging of biological samples | YALE UNIVERSITY (US) | 2026-03-17 | — | — | US | claimed |
| EP-4514596-B1 | METHOD FOR MAKING SILICONE HYDROGEL CONTACT LENSES | ALCON INC (CH) | 2026-03-04 | — | — | EP | claimed |
| EP-3759528-B1 | SILICONE HYDROGEL CONTACT LENSES | ALCON INC (CH) | 2026-03-04 | — | — | EP | claimed |
| WO-2025202518-A1 | MEASURE OF A QUINOLINATE AND TRYPTOPHAN CONCENTRATION | Institut National de la Santé et de la Recherche Médicale (FR) | 2025-10-02 | — | — | WO | claimed |
| US-20250276007-A1 | CARBAMOYLPHENYLBORONIC ACID-CONTAINING ACRYLIC MONOMERS AND USES THEREOF | ALCON INC (CH) | 2025-09-04 | — | — | US | claimed |
| EP-3872101-B1 | POLYMERIC PARTICLES | LIFE TECH AS (NO) | 2025-08-20 | — | — | EP | claimed |
| US-20250244308-A1 | METHODS AND SYSTEMS FOR PHYSICAL EXPANSION AND IMAGING OF BIOLOGICAL SAMPLES | UNIV YALE (US) | 2025-07-31 | — | — | US | claimed |
| US-20250223392-A1 | HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF | ALCON INC (CH) | 2025-07-10 | — | — | US | claimed |
| US-6271278-B1 | POROSITY OF COMPOSITES AND CROSSLINKING POLYMERS AND PARTICLES | PURDUE RESEARCH FOUNDATION | 2001-08-07 | — | — | US | claimed |
| WO-2001025285-A1 | LARGE-PORE CHROMATOGRAPHIC BEADS PREPARED BY SUSPENSION POLYMERIZATION | BIO-RAD LABORATORIES, INC. (US) | 2001-04-12 | — | — | WO | claimed |
| EP-0988108-A1 | HYDROGEL COMPOSITES AND SUPERPOROUS HYDROGEL COMPOSITES HAVING FAST SWELLING, HIGH MECHANICAL STRENGHT, AND SUPERABSORBENT PROPERTIES | PURDUE RESEARCH FOUNDATION (US) | 2000-03-29 | — | — | EP | claimed |
| US-5935429-A | MONOMER COMPRISING VINYL, ALLYL, OR ACRYLIC COMPOUND, CROSSLINKING AGENT | BIO-RAD LABORATORIES, INC. (US) | 1999-08-10 | — | — | US | claimed |
| WO-1998051408-A1 | HYDROGEL COMPOSITES AND SUPERPOROUS HYDROGEL COMPOSITES HAVING FAST SWELLING, HIGH MECHANICAL STRENGHT, AND SUPERABSORBENT PROPERTIES | PURDUE RESEARCH FOUNDATION (US) | 1998-11-19 | — | — | WO | claimed |
| EP-0852334-A1 | Chromatography columns with continuous beds formed in situ from aqueous solutions | BIO-RAD LABORATORIES, INC. (US) | 1998-07-08 | — | — | EP | claimed |
| US-5647979-A | One-step preparation of separation media for reversed-phase chromatography | BIO-RAD LABORATORIES, INC. (US) | 1997-07-15 | — | — | US | claimed |
| US-5645717-A | NON-SOLUBLE CROSSLINKED ACRYLIC POLYMER SEPARATORS; COMPRESSED BEDS, GELS | BIO-RAD LABORATORIES, INC. (US) | 1997-07-08 | — | — | US | claimed |
| US-4277581-A | HAIR CONDITIONERS | L'OREAL (FR) | 1981-07-07 | — | — | US | claimed |
| US-4201766-A | CROSSLINKED POLYAMINOAMIDE, QUATERNIZED CATIONIC POLYMER | L'OREAL (FR) | 1980-05-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250276007-A1 | CARBAMOYLPHENYLBORONIC ACID-CONTAINING ACRYLIC MONOMERS AND USES THEREOF | ADCY6, ADCY1, ADCY7 | ALDH1A1 2777/4885TSHR 2199/4885FGFR4 2135/4885 |
| US-12578320-B2 | Methods and systems for physical expansion and imaging of biological samples | KRT18, DSP, SMCHD1 | ALDH1A1 1765/4885TSHR 2214/4885FGFR4 1631/4885 |
| US-12638614-B2 | Method for making silicone hydrogel contact lenses | SMCHD1, CRYAA, CRYZ | ALDH1A1 2364/4885TSHR 1465/4885FGFR4 3499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.