Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL395101 | 0.81 | XDH (0.52) | MAPTLMNAALDH1A1CYP3A4MEN1 | |
| SCHEMBL8009682 | 0.81 | METAP2 (0.44) | MAPTLMNAALDH1A1CYP3A4MEN1 | |
| Hydrochloric Acid SCHEMBL27834553 | 0.79 | XDH (0.50) | MAPTLMNAALDH1A1CYP3A4MEN1 | |
| Hydrochloric Acid SCHEMBL8715979 | 0.79 | XDH (0.50) | MAPTLMNAALDH1A1CYP3A4MEN1 | |
| Iodide SCHEMBL28431948 | 0.78 | XDH (0.49) | MAPTLMNAALDH1A1CYP3A4MEN1 | |
| SCHEMBL2419681 | 0.78 | ALDH1A1 (0.48) | MAPTLMNAALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL5924343 | 0.78 | MAPT (0.47) | MAPTCYP2D6ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3574638 | 0.78 | MAPT (0.46) | MAPTALDH1A1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL4518438 | 0.78 | XDH (0.54) | MAPTLMNAALDH1A1CYP3A4MEN1 | |
| SCHEMBL20390648 | 0.78 | MEN1 (0.42) | MAPTLMNAALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12404265-B2 | Substituted pyridine derivatives as SARM1 inhibitors | NURA BIO, INC. (US) | 2025-09-02 | — | — | US | disclosed |
| CN-120208965-B | 4- (Pyridin-4-yl) -1H-imidazol-2-amine derivatives and compositions targeting gram-negative outer membrane assembly key protein machinery | 四川大学 | 2025-08-12 | — | — | CN | disclosed |
| CN-120208965-B | 4- (Pyridin-4-yl) -1H-imidazol-2-amine derivatives and compositions targeting gram-negative outer membrane assembly key protein machinery | 四川大学 | 2025-08-12 | — | — | CN | disclosed |
| CN-120208965-A | 4- (Pyridin-4-yl) -1H-imidazol-2-amine derivatives and compositions targeting gram-negative outer membrane assembly key protein machinery | 四川大学 | 2025-06-27 | — | — | CN | disclosed |
| CN-120208965-A | 4- (Pyridin-4-yl) -1H-imidazol-2-amine derivatives and compositions targeting gram-negative outer membrane assembly key protein machinery | 四川大学 | 2025-06-27 | — | — | CN | disclosed |
| US-11970481-B1 | Substituted pyridine derivatives as SARM1 inhibitors | NURA BIO, INC. (US) | 2024-04-30 | — | — | US | disclosed |
| US-20240116901-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | NURA BIO, INC. | 2024-04-11 | — | — | US | disclosed |
| US-20230339913-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | NURA BIO, INC. | 2023-10-26 | — | — | US | disclosed |
| US-20230339913-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | NURA BIO, INC. | 2023-10-26 | — | — | US | disclosed |
| EP-4192828-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | Nura Bio, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12404265-B2 | Substituted pyridine derivatives as SARM1 inhibitors | SARM1, SARNP, ADRM1 | MAPT 45/4885LMNA 2012/4885CYP2D6 3763/4885 |
| US-11970481-B1 | Substituted pyridine derivatives as SARM1 inhibitors | SARM1, SARNP, ADRM1 | MAPT 45/4885LMNA 2012/4885CYP2D6 3763/4885 |
| US-20230339913-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | SARM1, SARNP, ADRM1 | MAPT 45/4885LMNA 2012/4885CYP2D6 3763/4885 |
| US-20240116901-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | SARM1, SARNP, ADRM1 | MAPT 45/4885LMNA 2012/4885CYP2D6 3763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.