SCHEMBL25214545

SCHEMBL25214545

O=C(O)C=Cc1ccc(C=CC(=O)c2ccccc2)cc1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1B1 Q16678 6/20 0.81
MAPT P10636 5/20 0.81
MAOB P27338 4/20 0.81
BCHE P06276 3/20 0.81
LMNA P02545 2/20 0.81
PLIN1 O60240 1/20 0.81
TNFRSF1A P19438 1/20 0.81
ACHE P22303 1/20 0.81
RECQL P46063 1/20 0.81
PLIN5 Q00G26 1/20 0.81
ABHD5 Q8WTS1 1/20 0.81
CYP3A4 P08684 4/20 0.76
KMT2A Q03164 3/20 0.76
NFKB1 P19838 2/20 0.76
NFKB2 Q00653 2/20 0.76
RELA Q04206 2/20 0.76
HSPD1 P10809 2/20 0.76
HSPE1 P61604 2/20 0.76
RAB9A P51151 2/20 0.76
PKM P14618 1/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25202483 1.00 CYP1B1 (0.81) CYP1B1MAPTMAOBBCHELMNA
SCHEMBL25193884 1.00 CYP1B1 (0.81) CYP1B1MAPTMAOBBCHELMNA
SCHEMBL6881035 1.00 CYP1B1 (0.81) CYP1B1MAPTMAOBBCHELMNA
Chalcone SCHEMBL4385450 0.96 CYP1B1 (0.88) CYP1B1MAPTMAOBBCHELMNA
Chalcone SCHEMBL4385453 0.96 CYP1B1 (0.88) CYP1B1MAPTMAOBBCHELMNA
SCHEMBL27541712 0.94 CYP1B1 (0.78) CYP1B1MAPTMAOBBCHELMNA
SCHEMBL5196588 0.94 CYP1B1 (0.78) CYP1B1MAPTMAOBBCHELMNA
SCHEMBL5196586 0.94 CYP1B1 (0.78) CYP1B1MAPTMAOBBCHELMNA
SCHEMBL9915665 0.94 CYP1B1 (0.91) CYP1B1MAPTMAOBBCHELMNA
SCHEMBL8431772 0.94 CYP1B1 (0.91) CYP1B1MAPTMAOBBCHELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B CYP1B1 230/4885MAPT 3297/4885MAOB 1004/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 CYP1B1 1027/4885MAPT 3512/4885MAOB 2435/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 CYP1B1 1027/4885MAPT 3512/4885MAOB 2435/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.