Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 5/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 7/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 6/20 | 0.34 |
| ▸ | PPARA | Q07869 | 6/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.34 |
| ▸ | TLR2 | O60603 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | FABP4 | P15090 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4791448 | 1.00 | APEX1 (0.39) | APEX1CES1CES2GRIK1EP300 | |
| SCHEMBL7677056 | 0.94 | AKR1B1 (0.43) | CES1CES2EP300TSHRFAAH | |
| SCHEMBL7674491 | 0.93 | TSHR (0.46) | EP300TSHRFAAHPPARGALDH1A1 | |
| SCHEMBL1843576 | 0.93 | TSHR (0.46) | EP300TSHRFAAHPPARGALDH1A1 | |
| SCHEMBL7679499 | 0.88 | FFAR3 (0.37) | CES1CES2GRIK1EP300TSHR | |
| SCHEMBL4732392 | 0.80 | CES1 (0.41) | APEX1CES1CES2GRIK1EP300 | |
| SCHEMBL7556833 | 0.79 | GRIK1 (0.47) | APEX1CES1CES2GRIK1EP300 | |
| SCHEMBL285080 | 0.79 | GRIK1 (0.47) | APEX1CES1CES2GRIK1EP300 | |
| SCHEMBL4433665 | 0.79 | GRIK1 (0.47) | APEX1CES1CES2GRIK1EP300 | |
| SCHEMBL2522759 | 0.79 | ALDH1A1 (0.37) | GRIK1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373715-A2 | OMEGA-FUNCTIONALIZED POLYMERS, JUNCTION-FUNCTIONALIZED BLOCK COPOLYMERS, POLYMER BIOCONJUGATES, AND RADICAL CHAIN EXTENSION POLYMERIZATION | University Of Washington (US) | 2011-10-12 | — | — | EP | disclosed |