SCHEMBL252198

SCHEMBL252198

O=C(Cl)CN1C(=O)c2ccccc2C1=O

nearest known ligand 0.68

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.68
CA9 Q16790 1/20 0.68
ALDH1A1 P00352 6/20 0.58
NPSR1 Q6W5P4 2/20 0.58
KDM4E B2RXH2 2/20 0.58
MAPT P10636 2/20 0.58
RAB9A P51151 1/20 0.58
MEN1 O00255 3/20 0.56
KMT2A Q03164 3/20 0.56
GSK3B P49841 1/20 0.54
POLB P06746 2/20 0.51
TSHR P16473 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
NPC1 O15118 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30097999 0.83 KDM4E (0.73) ALDH1A1NPSR1KDM4EMAPTMEN1
SCHEMBL8940040 0.83 CA12 (0.73) CA12CA9ALDH1A1NPSR1KDM4E
SCHEMBL30632370 0.82 CA12 (0.47) CA12CA9ALDH1A1NPSR1KDM4E
SCHEMBL11148327 0.81 CA12 (0.70) CA12CA9ALDH1A1NPSR1KDM4E
SCHEMBL29744481 0.81 CA12 (1.00) CA12CA9ALDH1A1NPSR1KDM4E
SCHEMBL522649 0.81 CA12 (1.00) CA12CA9ALDH1A1NPSR1KDM4E
SCHEMBL11571278 0.81 KDM4E (0.59) CA12CA9ALDH1A1NPSR1KDM4E
SCHEMBL7437619 0.80 CA12 (0.63) CA12CA9ALDH1A1NPSR1KDM4E
SCHEMBL29642483 0.80 ALDH1A1 (0.57) CA12CA9ALDH1A1KDM4EMEN1
SCHEMBL3756580 0.80 ALDH1A1 (0.57) CA12CA9ALDH1A1KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 397 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114181133-B Preparation method of glycine derivative acetamide compound 上海应用技术大学 2023-04-28 CN claimed
CN-114181133-A Preparation method of glycine derived acetamide compound 上海应用技术大学 2022-03-15 CN claimed
US-20110039682-A1 METHOD FOR SYNTHESIZING ONE-DIMENSIONAL HELICAL NANOPOROUS STRUCTURES AND METHOD FOR SYNTHESIZING GLYCINE-DERIVED SURFACTANT FOR SYNTHESIZING HELICAL NANOPOROUS STRUCTURES THERMOLON KOREA CO., LTD. (KR) 2011-02-17 US claimed
WO-2009131324-A2 METHOD FOR SYNTHESIZING ONE-DIMENSIONAL HELICAL NANOPOROUS STRUCTURES AND METHOD FOR SYNTHESIZING GLYCINE-DERIVED SURFACTANT FOR SYNTHESIZING HELICAL NANOPOROUS STRUCTURES THERMOLON KOREA CO.,LTD. (KR) 2009-10-29 WO claimed
US-3957761-A Process for the production of 1-aminomethyl-6-phenyl-4h-s-triazolo-[4,3-a][1]benzodiazepines and intermediates THE UPJOHN COMPANY (US) 1976-05-18 US claimed
EP-4073062-B1 FUNCTIONALIZED HETEROCYCLIC COMPOUNDS AS MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) RYVU THERAPEUTICS S A (PL) 2026-04-29 EP disclosed
US-12564583-B2 Small molecules against cereblon to enhance effector T cell function Lee Moffitt Cancer Center and Research Institute, Inc. (US) 2026-03-03 US disclosed
US-12435080-B2 sGC stimulators TISENTO THERAPEUTICS INC. (US) 2025-10-07 US disclosed
EP-3749306-B1 NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITORS AND METHODS FOR USE OF THE SAME UNIV INDIANA TRUSTEES (US) 2025-09-03 EP disclosed
US-20250243177-A1 sGC STIMULATORS CYCLERION THERAPEUTICS, INC. 2025-07-31 US disclosed
EP-3924349-B1 AMINO ACID DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES THE ROSKAMP INST (US) 2025-06-25 EP disclosed
CN-119838022-A Amatoxin conjugates containing branched linkers 杭州多禧生物科技有限公司 2025-04-18 CN disclosed
US-4141901-A REDUCING AN AZIDO DERIVATIVE SHIONOGI & CO., LTD. (JP) 1979-02-27 US disclosed
US-4140688-A Tricyclic (azeto-isoquinoline) β-lactams SMITHKLINE CORPORATION (US) 1979-02-20 US disclosed
US-4122262-A ANTIBACTERIAL SMITHKLINE CORPORATION (US) 1978-10-24 US disclosed
US-4118742-A VIRICIDES ELI LILLY AND COMPANY (US) 1978-10-03 US disclosed
US-4089956-A 7-Acylamino-8-oxo-3-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid derivatives and bactericidal compositions and use thereof SMITHKLINE CORPORATION (US) 1978-05-16 US disclosed
US-4085100-A Intermediate for dephthaloylation of azetidinone compounds SMITHKLINE CORPORATION (US) 1978-04-18 US disclosed
US-3957761-A Process for the production of 1-aminomethyl-6-phenyl-4h-s-triazolo-[4,3-a][1]benzodiazepines and intermediates THE UPJOHN COMPANY (US) 1976-05-18 US disclosed
US-3943123-A ANTIBIOTIC KONINKLIJKE NEDERLANDSCHE GIST-EN SPIRITUSFABRIEK N.V. (NL) 1976-03-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12435080-B2 sGC stimulators GUCY1A2, PRKG1, PDE2A CA12 4557/4885CA9 3306/4885ALDH1A1 2355/4885
US-12564583-B2 Small molecules against cereblon to enhance effector T cell function CRBN, CD4, ICOS CA12 3365/4885CA9 2216/4885ALDH1A1 2373/4885
US-20250243177-A1 sGC STIMULATORS GUCY1A1, PTGIS, GUCY1B1 CA12 4537/4885CA9 3829/4885ALDH1A1 1325/4885
US-20110039682-A1 METHOD FOR SYNTHESIZING ONE-DIMENSIONAL HELICAL NANOPOROUS STRUCTURES AND METHOD FOR SYNTHESIZING GLYCINE-DERIVED SURFACTANT FOR SYNTHESIZING HELICAL NANOPOROUS STRUCTURES GGH, STOM, GLRB CA12 167/4885CA9 678/4885ALDH1A1 4783/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.