Lonazolac

Lonazolac

SCHEMBL25221

O=C(O)Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 1.00
DRD2 P14416 1/20 1.00
PTGES O14684 9/20 0.86
ALOX5 P09917 8/20 0.86
ALDH1A1 P00352 3/20 0.82
AGTR1 P30556 1/20 0.65
KMT2A Q03164 1/20 0.65
CCNE1 P24864 3/20 0.63
CDK2 P24941 3/20 0.63
MAPT P10636 2/20 0.61
HPGD P15428 2/20 0.61
USP2 O75604 1/20 0.61
NPSR1 Q6W5P4 1/20 0.61
HSD17B10 Q99714 1/20 0.61
AURKA O14965 2/20 0.58
LMNA P02545 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lonazolac SCHEMBL287156 0.99 KDM4E (0.97) KDM4EDRD2PTGESALOX5ALDH1A1
Lonazolac SCHEMBL1478078 0.99 KDM4E (0.97) KDM4EDRD2PTGESALOX5ALDH1A1
SCHEMBL11245260 0.95 KDM4E (0.90) KDM4EDRD2PTGESALOX5ALDH1A1
SCHEMBL11166545 0.94 KDM4E (0.90) KDM4EDRD2PTGESALOX5ALDH1A1
SCHEMBL10877279 0.91 KDM4E (0.83) KDM4EDRD2PTGESALOX5ALDH1A1
SCHEMBL10407060 0.90 KDM4E (1.00) KDM4EDRD2PTGESALOX5ALDH1A1
SCHEMBL12608902 0.90 KDM4E (0.81) KDM4EDRD2PTGESALOX5ALDH1A1
SCHEMBL3475488 0.90 KDM4E (0.81) KDM4EDRD2PTGESALOX5ALDH1A1
Lonazolac SCHEMBL10577835 0.88 PTGES (1.00) KDM4EDRD2PTGESALOX5ALDH1A1
SCHEMBL11258042 0.88 KDM4E (0.79) KDM4EDRD2PTGESALOX5ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5295 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4674894-A2 COPOLYMERS OF N-VINYLPYRROLIDONE WITH FUNCTIONALIZED MALEIC ACID MOIETIES Hemoteq AG (DE) 2026-01-07 EP claimed
US-20260000741-A1 METHOD OF AMELIORATING A PRO-INFLAMMATORY IMMUNOPHENOTYPE IN FARBER DISEASE SUBJECTS BY REPEATED ADMINISTRATION OF A RECOMBINANT HUMAN ACID CERAMIDASE ACERAGEN INC (US) 2026-01-01 US claimed
EP-4663688-A2 CROSSLINKERS Hemoteq AG (DE) 2025-12-17 EP claimed
EP-3699174-B1 COMPOSITION FOR PREVENTING OR TREATING TNF-RELATED DISEASES, CONTAINING DERIVATIVE AS ACTIVE INGREDIENT, AND METHOD FOR INHIBITING TNF ACTIVITY BY USING SAME ILAB (KR) 2025-11-12 EP claimed
US-20250041208-A1 NEW INJECTABLE COMBINATION FORMULATION NANEXA AB (SE) 2025-02-06 US claimed
EP-4470565-A1 METHOD FOR PREVENTING OR TREATING DISEASE OR DISORDER ASSOCIATED WITH ANTINEOPLASTIC AGENT OnQuality Pharmaceuticals China Ltd. (CN) 2024-12-04 EP claimed
US-RE50218-E1 Non-steroidal anti-inflammatory ophthalmic compositions SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) 2024-11-26 US claimed
EP-4444277-A1 NEW INJECTABLE COMBINATION FORMULATION Nanexa AB (SE) 2024-10-16 EP claimed
CN-118742325-A Methods for preventing or treating diseases or conditions associated with antineoplastic agents 上海岸阔医药科技有限公司 2024-10-01 CN claimed
US-20240041935-A1 PREVENTION AND TREATMENT OF REPRODUCTIVE FAILURE BY REGENERATIVE CELLS AND ADJUVANTS CREATIVE MEDICAL TECHNOLOGIES, INC. (US) 2024-02-08 US claimed
EP-0374602-A1 Lipoxygenase inhibiting compounds ABBOTT LABORATORIES (US) 1990-06-27 EP claimed
US-4914121-A CURING IMMUNITY DISEASES AND NEPHROPATHY SANWA KAGAKU KENKYUSHO CO., LTD. (JP) 1990-04-03 US claimed
EP-0336147-A2 Diethylene glycol monoesters, process for their preparation and their use as medicines Merckle GmbH (DE) 1989-10-11 EP claimed
EP-0335164-A2 Ester derivatives of neopentanol, process for their preparation and their use as medicines Merckle GmbH (DE) 1989-10-04 EP claimed
WO-1989008119-A1 HIGH MOLECULAR WEIGHT PRODRUG DERIVATIVES OF ANTI-INFLAMMATORY DRUGS SELCH LARSEN CLAUS (DK) 1989-09-08 WO claimed
EP-0331471-A1 High molecular weight prodrug derivatives of antiinflammatory drugs Larsen, Claus Selch (DK) 1989-09-06 EP claimed
EP-0299504-A1 A process for the preparation of 1-phenyl-3-(4-chlorophenyl)-pyrazol-4-ylacetic acid and its calcium salt SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu (CS) 1989-01-18 EP claimed
EP-0272704-A2 Use of pyrazole derivatives in the treatment of immunity diseases and nephropathy SANWA KAGAKU KENKYUSHO CO., LTD. (JP) 1988-06-29 EP claimed
US-4325962-A ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIDYRETICS BYK-GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1982-04-20 US claimed
US-4146721-A ANALGESICS, ANTIINFLAMMATORY AGENTS AND ANTIPYRETICS BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1979-03-27 US claimed