Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tegaserod. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 known ✓ | Q13639 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 5/20 | 0.60 |
| ▸ | HTR2C | P28335 | 5/20 | 0.60 |
| ▸ | HTR1D | P28221 | 3/20 | 0.60 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.60 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.60 |
| ▸ | DRD2 | P14416 | 2/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.60 |
| ▸ | DRD4 | P21917 | 2/20 | 0.60 |
| ▸ | HTR2A | P28223 | 2/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.60 |
| ▸ | DRD3 | P35462 | 2/20 | 0.60 |
| ▸ | HTR2B | P41595 | 2/20 | 0.60 |
| ▸ | HTR3A | P46098 | 2/20 | 0.60 |
| ▸ | HTR5A | P47898 | 2/20 | 0.60 |
| ▸ | HTR6 | P50406 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | DRD5 | P21918 | 1/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tegaserod SCHEMBL4638118 | 1.00 | HTR1A (0.60) | HTR1AHTR2CHTR1DADRB1ADRB3 | |
| Tegaserod SCHEMBL4319900 | 0.99 | HTR1A (0.61) | HTR1AHTR2CHTR1DADRB1ADRB3 | |
| Tegaserod SCHEMBL3910638 | 0.97 | HTR1A (0.61) | HTR1AHTR2CHTR1DADRB1ADRB3 | |
| Tegaserod SCHEMBL3890334 | 0.97 | HTR1A (0.61) | HTR1AHTR2CHTR1DADRB1ADRB3 | |
| SCHEMBL13036130 | 0.96 | HTR1A (0.55) | HTR1AHTR2CHTR1DADRB1ADRB3 | |
| Tegaserod SCHEMBL4636808 | 0.94 | HTR1A (0.62) | HTR1AHTR2CHTR1DADRB1ADRB3 | |
| Tegaserod SCHEMBL4637068 | 0.94 | HTR1A (0.62) | HTR1AHTR2CHTR1DADRB1ADRB3 | |
| Tegaserod SCHEMBL4637335 | 0.93 | HTR1A (0.61) | HTR1AHTR2CHTR1DADRB1ADRB3 | |
| Tegaserod SCHEMBL3229259 | 0.93 | HTR1A (0.63) | HTR1AHTR2CHTR1DADRB1ADRB3 | |
| Tegaserod SCHEMBL3892146 | 0.93 | HTR1A (0.63) | HTR1AHTR2CHTR1DADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110251254-A1 | NOVEL SALT OF TEGASEROD | MYLAN INDIA PRIVATE LIMITED (IN) | 2011-10-13 | — | — | US | claimed |
| EP-2240445-A1 | NOVEL SALT OF TEGASEROD | Generics (UK) Limited (GB) | 2010-10-20 | — | — | EP | claimed |
| WO-2009092994-A1 | NOVEL SALT OF TEGASEROD | GENERICS [UK] LIMITED (GB) | 2009-07-30 | — | — | WO | claimed |
| US-20110251254-A1 | NOVEL SALT OF TEGASEROD | MYLAN INDIA PRIVATE LIMITED (IN) | 2011-10-13 | — | — | US | disclosed |
| US-20110251254-A1 | NOVEL SALT OF TEGASEROD | MYLAN INDIA PRIVATE LIMITED (IN) | 2011-10-13 | — | — | US | disclosed |
| CN-101990533-A | New salts of tegaserod | GENERICS UK LTD | 2011-03-23 | — | — | CN | disclosed |
| EP-2240445-A1 | NOVEL SALT OF TEGASEROD | Generics (UK) Limited (GB) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009092994-A1 | NOVEL SALT OF TEGASEROD | GENERICS [UK] LIMITED (GB) | 2009-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251254-A1 | NOVEL SALT OF TEGASEROD | SLC10A2, CEL, SI | HTR4 141/4885HTR1A 373/4885HTR2C 735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.