Sugi Predict

Sugi Predict / Compounds / SCHEMBL25224949

SCHEMBL25224949

SCHEMBL25224949

NS(=O)(=O)c1cc([N+](=O)[O-])c(NCC2CCOCC2)c2[nH]cnc12

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RORC P51449 1/20 0.36
▸ ALDH1A1 P00352 2/20 0.35
▸ HTT P42858 2/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ LMNA P02545 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ LRRK2 Q5S007 1/20 0.34
▸ CSF1R P07333 4/20 0.33
▸ CNR2 P34972 1/20 0.32
▸ SCN5A Q14524 1/20 0.32
▸ PTGS1 P23219 1/20 0.32
▸ PTGS2 P35354 1/20 0.32
▸ PRKCQ Q04759 4/20 0.31
▸ MAPT P10636 1/20 0.31
▸ SMN1; SMN2 Q16637 1/20 0.31
▸ CA1 P00915 1/20 0.31
▸ CA2 P00918 1/20 0.31
▸ CA7 P43166 1/20 0.31
▸ CA13 Q8N1Q1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30805804 0.86 KDM4E (0.34) ALDH1A1HTTKDM4EMEN1LMNA
SCHEMBL30414356 0.86 KMT2A (0.37) ALDH1A1HTTKDM4EMEN1LMNA
SCHEMBL25219639 0.86 KMT2A (0.37) ALDH1A1HTTKDM4EMEN1LMNA
SCHEMBL25640635 0.83 ALDH1A1 (0.35) ALDH1A1HTTKDM4EMEN1LMNA
SCHEMBL31019217 0.83 KCNH2 (0.39) ALDH1A1LRRK2CSF1RCNR2PRKCQ
SCHEMBL30414565 0.82 BCL2 (0.38) MAPT
SCHEMBL30413781 0.79 BCL2 (0.39) ALDH1A1PTGS1PTGS2MAPTKCNH2
SCHEMBL25263010 0.77 RORC (0.39) RORCALDH1A1HTTKDM4EMEN1
SCHEMBL26444023 0.76 GSTP1 (0.42) ALDH1A1MEN1LMNAKMT2ACSF1R
SCHEMBL30447634 0.75 MEN1 (0.31) MEN1KMT2ACA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116217566-B Anti-apoptosis protein BCL-2 inhibitor, pharmaceutical composition and application thereof 杭州和正医药有限公司 2025-05-23 — — CN disclosed
US-20250034135-A1 ANTI-APOPTOTIC PROTEIN BCL-2 INHIBITOR, PHARMACEUTICAL COMPOSITION AND USES THEREOF Hangzhou Healzen Therapeutics Co., Ltd. (CN) 2025-01-30 — — US disclosed
EP-4442685-A1 ANTI-APOPTOTIC PROTEIN BCL-2 INHIBITOR, PHARMACEUTICAL COMPOSITION AND USES THEREOF Hangzhou HealZen Therapeutics Co., Ltd. (CN) 2024-10-09 — — EP disclosed
CN-118215661-A Compounds as BCL-2 inhibitors 重庆复创医药研究有限公司 2024-06-18 — — CN disclosed
WO-2023104043-A1 ANTI-APOPTOTIC PROTEIN BCL-2 INHIBITOR, PHARMACEUTICAL COMPOSITION AND USES THEREOF 杭州和正医药有限公司 2023-06-15 — — WO disclosed
CN-116217566-A Anti-apoptosis protein BCL-2 inhibitor, pharmaceutical composition and application thereof 杭州和正医药有限公司 2023-06-06 — — CN disclosed
US-20230128137-A1 BENZO FIVE-MEMBERED CYCLIC COMPOUND MEDSHINE DISCOVERY INC. (CN) 2023-04-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230128137-A1 BENZO FIVE-MEMBERED CYCLIC COMPOUND BCL2, BAX, BCL2L1 RORC 2951/4885ALDH1A1 3365/4885HTT 3325/4885
US-20250034135-A1 ANTI-APOPTOTIC PROTEIN BCL-2 INHIBITOR, PHARMACEUTICAL COMPOSITION AND USES THEREOF BCL2, BAX, BCL2L1 RORC 1531/4885ALDH1A1 4614/4885HTT 2858/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.