Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8853408 | 0.86 | ALDH1A1 (0.38) | KDM4EALDH1A1CYP2A6TSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL2522928 | 0.86 | ALDH1A1 (0.38) | KDM4EALDH1A1CYP2A6TSHRCYP1A2 | |
| Fluoride Ion SCHEMBL7643349 | 0.83 | ALDH1A1 (0.38) | KDM4EALDH1A1CYP2A6TSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL5689511 | 0.81 | KDM4E (0.37) | KDM4EALDH1A1CYP2A6TSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL9063494 | 0.79 | KDM4E (0.34) | KDM4EALDH1A1CYP2A6TSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL7935633 | 0.77 | KDM4E (0.33) | KDM4EALDH1A1CYP2A6TSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL6523163 | 0.77 | KDM4E (0.33) | KDM4EALDH1A1CYP2A6TSHRCYP1A2 | |
| Hydrochloric Acid SCHEMBL8853186 | 0.76 | KDM4E (0.32) | KDM4EALDH1A1CYP2A6HSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL8628885 | 0.75 | TNF (0.35) | KDM4EALDH1A1CYP2A6TSHRHSD17B10 | |
| SCHEMBL7037711 | 0.74 | KDM4E (0.41) | KDM4EALDH1A1CYP2A6TSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184319-A1 | Process for the production of organic polymeric profiles | CLARIANT INTERNATIONAL LTD. (CH) | 2010-05-12 | — | — | EP | disclosed |