SCHEMBL2522935

SCHEMBL2522935

C[SiH](c1ccccc1)c1ccc([SiH](C)c2ccccc2)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 6/20 0.37
ACHE P22303 2/20 0.37
LMNA P02545 1/20 0.37
ALOX12 P18054 1/20 0.37
ALDH1A1 P00352 2/20 0.33
CA4 P22748 2/20 0.32
DAO P14920 1/20 0.32
NAPRT Q6XQN6 1/20 0.32
TP53 P04637 1/20 0.32
APOBEC3A P31941 1/20 0.30
APOBEC3G Q9HC16 1/20 0.30
CA1 P00915 2/20 0.30
CA2 P00918 2/20 0.30
CA9 Q16790 2/20 0.30
TDP1 Q9NUW8 2/20 0.30
CA12 O43570 1/20 0.30
GLA P06280 1/20 0.30
CA3 P07451 1/20 0.30
CA14 Q9ULX7 1/20 0.30
CA7 P43166 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL124751 0.97 TSHR (0.39) TSHRACHELMNAALOX12ALDH1A1
Phosphine SCHEMBL28225524 0.93 TSHR (0.37) TSHRACHELMNAALOX12ALDH1A1
Fluoride SCHEMBL27639907 0.93 TSHR (0.37) TSHRACHELMNAALOX12ALDH1A1
SCHEMBL2599044 0.93 TSHR (0.37) TSHRACHELMNAALOX12ALDH1A1
SCHEMBL23700634 0.91 ALDH1A1 (0.42) ALDH1A1CA1CA2TDP1
SCHEMBL12191027 0.89 ACHE (0.50) TSHRACHELMNAALOX12ALDH1A1
SCHEMBL29940873 0.88 LMNA (0.33) TSHRACHELMNAALOX12ALDH1A1
SCHEMBL28484780 0.87 CA12 (0.48) LMNAALDH1A1CA4CA1CA2
SCHEMBL4141596 0.85 ACHE (0.32) TSHRACHELMNAALOX12ALDH1A1
SCHEMBL29776860 0.85 ALDH1A1 (0.50) ALDH1A1CA1CA2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12497511-B2 Crosslinkable organopolysiloxane compositions WACKER CHEMIE AG (DE) 2025-12-16 US disclosed
US-12187854-B2 Crosslinkable organosiloxane compositions WACKER CHEMIE AG (DE) 2025-01-07 US disclosed
US-12110393-B2 Crosslinkable organopolysiloxane compositions WACKER CHEMIE AG (DE) 2024-10-08 US disclosed
CN-112996841-B Crosslinkable organosiloxane compositions 瓦克化学股份公司 2022-12-27 CN disclosed
CN-111936582-B Crosslinkable organosiloxane compositions 瓦克化学股份公司 2022-06-17 CN disclosed
CN-111936556-B Crosslinkable organosiloxane compositions 瓦克化学股份公司 2022-05-03 CN disclosed
EP-3837317-B1 CROSSLINKABLE ORGANOSILOXANE COMPOSITIONS WACKER CHEMIE AG (DE) 2022-04-20 EP disclosed
US-20210347952-A1 CROSSLINKABLE ORGANOPOLYSILOXANE COMPOSITIONS WACKER CHEMIE AG (DE) 2021-11-11 US disclosed
US-20210309856-A1 CROSSLINKABLE ORGANOPOLYSILOXANE COMPOSITIONS WACKER CHEMIE AG (DE) 2021-10-07 US disclosed
US-20210238366-A1 CROSSLINKABLE ORGANOSILOXANE COMPOSITIONS WACKER CHEMIE AG (DE) 2021-08-05 US disclosed
US-8252882-B2 Polyimide resin produced by using silphenylene compound SHIN-ETSU CHEMICAL CO., LTD. (JP) 2012-08-28 US disclosed
US-8048978-B2 Silphenylene compound and process for producing the same SHIN-ETSU CHEMICAL CO., LTD. (JP) 2011-11-01 US disclosed
US-20110251371-A1 POLYIMIDE RESIN PRODUCED BY USING SILPHENYLENE COMPOUND SUGO MICHIHIRO 2011-10-13 US disclosed
US-20090156753-A1 SILPHENYLENE COMPOUND AND PROCESS FOR PRODUCING THE SAME SHIN-ETSU CHEMICAL CO., LTD. (JP) 2009-06-18 US disclosed
US-7294682-B2 Curable silicone resin composition SHIN-ETSU CHEMICAL CO., LTD. (JP) 2007-11-13 US disclosed
EP-0661332-B1 Silicon-containing reactive polymer and curable resin composition comprising the same KANEGAFUCHI CHEMICAL IND (JP) 2000-04-12 EP disclosed
EP-0661332-A2 Silicon-containing reactive polymer and curable resin composition comprising the same Kanegafuchi Chemical Industry Co., Ltd. (JP) 1995-07-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090156753-A1 SILPHENYLENE COMPOUND AND PROCESS FOR PRODUCING THE SAME CRBN, KIT, EPCAM TSHR 3183/4885ACHE 4022/4885LMNA 2687/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.