Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | CRHBP | P24387 | 2/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GSR | P00390 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL147785 | 0.89 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL11124464 | 0.81 | MAPT (0.47) | ALDH1A1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL4611261 | 0.80 | NPC1 (0.46) | ALDH1A1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL28153546 | 0.80 | ADRA2C (0.42) | ALDH1A1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL5025924 | 0.78 | MEN1 (0.42) | ALDH1A1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL5880844 | 0.77 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL6282927 | 0.76 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL8331506 | 0.73 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL4578482 | 0.73 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL162872 | 0.72 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2ACRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2352724-B1 | ARYL GUANIDINE F1F0-ATPASE INHIBITORS AND THEIR MEDICAL USE | UNIV MICHIGAN (US) | 2015-04-22 | — | — | EP | disclosed |
| US-8497307-B2 | Aryl guanidine F1F0-ATPase inhibitors and related methods | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-07-30 | — | — | US | disclosed |
| US-20110251200-A1 | ARYL GUANIDINE F1F0-ATPASE INHIBITORS AND RELATED METHODS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251200-A1 | ARYL GUANIDINE F1F0-ATPASE INHIBITORS AND RELATED METHODS | ATP5F1A, ATP5F1D, ATP5F1B | KCNA3 2218/4885ALDH1A1 1006/4885MEN1 3806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.