Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CRHBP | P24387 | 2/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11124464 | 0.89 | MAPT (0.47) | ALDH1A1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL4611261 | 0.87 | NPC1 (0.46) | ALDH1A1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL162872 | 0.83 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL147785 | 0.80 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL1770692 | 0.79 | ESR1 (0.43) | ALDH1A1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL6282927 | 0.79 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL2522995 | 0.77 | KCNA3 (0.39) | ALDH1A1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL5025924 | 0.77 | MEN1 (0.42) | ALDH1A1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL8812805 | 0.77 | HSD17B10 (0.43) | ALDH1A1LMNATSHRMAPK1HCAR3 | |
| SCHEMBL2522993 | 0.77 | HTR1A (0.40) | ESR1TP53HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11129790-B2 | Chemo-enzymatic site-specific modification of peptides and proteins to form cleavable conjugates | NORTHEASTERN UNIVERSITY (US) | 2021-09-28 | — | — | US | disclosed |
| US-20180369131-A1 | Chemo-Enzymatic Site-Specific Modification of Peptides and Proteins to Form Cleavable Conjugates | NORTHEASTERN UNIVERSITY | 2018-12-27 | — | — | US | disclosed |
| US-7115658-B2 | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase | AGOURON PHARMACEUTICALS, INC. (US) | 2006-10-03 | — | — | US | disclosed |
| US-20040023958-A1 | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same | AGOURON PHARMACEUTICALS, INC. | 2004-02-05 | — | — | US | disclosed |
| WO-2003095441-A1 | INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME | PFIZER INC. (US) | 2003-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180369131-A1 | Chemo-Enzymatic Site-Specific Modification of Peptides and Proteins to Form Cleavable Conjugates | GLUL, QPCT, DNPEP | ALDH1A1 3701/4885MEN1 815/4885KMT2A 857/4885 |
| US-11129790-B2 | Chemo-enzymatic site-specific modification of peptides and proteins to form cleavable conjugates | GLUL, QPCT, DNPEP | ALDH1A1 3701/4885MEN1 815/4885KMT2A 857/4885 |
| US-20040023958-A1 | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same | POLRMT, RNGTT, RNASE1 | ALDH1A1 729/4885MEN1 4865/4885KMT2A 3031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.