Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19834819 | 0.92 | GAA (0.49) | SMN1; SMN2MAPTNPC1RAB9ATSHR | |
| SCHEMBL25278094 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL25273247 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL25277190 | 0.82 | HDAC3 (0.50) | L3MBTL1 | |
| SCHEMBL25278785 | 0.77 | ALDH1A1 (0.47) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL25735232 | 0.75 | ALDH1A1 (0.48) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL19834778 | 0.75 | GAA (0.55) | SMN1; SMN2MAPTNPC1RAB9ALMNA | |
| SCHEMBL19834771 | 0.74 | HDAC3 (0.59) | L3MBTL1 | |
| SCHEMBL25735183 | 0.73 | PABPC1 (0.45) | SMN1; SMN2MAPTNPC1RAB9AKDM4E | |
| SCHEMBL25735184 | 0.73 | PABPC1 (0.45) | SMN1; SMN2MAPTNPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116332818-B | Tetrahydropyrrole derivatives and their use | 王喆明 | 2023-12-15 | — | — | CN | disclosed |
| CN-116332818-A | Tetrahydropyrrole derivatives and their use | 王喆明 | 2023-06-27 | — | — | CN | disclosed |
| US-20230192651-A1 | Pyrrolidine Derivative and Use Thereof | WANG, ZHEMING (CN) | 2023-06-22 | — | — | US | disclosed |
| US-20230192651-A1 | Pyrrolidine Derivative and Use Thereof | WANG, ZHEMING (CN) | 2023-06-22 | — | — | US | disclosed |
| US-20230192651-A1 | Pyrrolidine Derivative and Use Thereof | WANG, ZHEMING (CN) | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192651-A1 | Pyrrolidine Derivative and Use Thereof | NAMPT, NAPRT, NNMT | SMN1; SMN2 1560/4885MAPT 1410/4885NPC1 1650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.