Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | MPI | P34949 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.57 |
| ▸ | RELA | Q04206 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | APP | P05067 | 11/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | BRD4 | O60885 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2521161 | 0.94 | MAPT (0.71) | MAPTKDM4EL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL2518215 | 0.94 | MAPT (0.71) | MAPTKDM4EL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL2518129 | 0.93 | MAPT (0.69) | MAPTKDM4EL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL5594397 | 0.90 | MAPT (0.77) | MAPTKDM4EL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL2523705 | 0.85 | MAPT (0.46) | MAPTKDM4EL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL2523696 | 0.85 | MAPT (0.46) | MAPTKDM4EL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL3325310 | 0.79 | MAPT (0.53) | MAPTKDM4EL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL113821 | 0.78 | MAPT (1.00) | MAPTKDM4EL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL7530866 | 0.78 | GLS (0.50) | ALDH1A1KMT2AHTT | |
| SCHEMBL5594566 | 0.77 | KDM4E (0.89) | MAPTKDM4EL3MBTL1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324243-B2 | Derivatives of the aminated hydroxyquinoline class for treating cancers | BIOPHARMED (FR) | 2012-12-04 | — | — | US | claimed |
| US-20100120856-A1 | Derivatives of the Aminated Hydroxyquinoline Class For Treating Cancers | BIOPHARMED (FR) | 2010-05-13 | — | — | US | claimed |
| US-20130102630-A1 | Derivatives of the Aminated Hydroxyquinoline Class For Treating Cancers | BIOPHARMED (FR) | 2013-04-25 | — | — | US | disclosed |
| US-8324243-B2 | Derivatives of the aminated hydroxyquinoline class for treating cancers | BIOPHARMED (FR) | 2012-12-04 | — | — | US | disclosed |
| US-20110251238-A1 | PPAR AGONIST COMPOSITIONS AND METHODS OF USE | BIOPHARMED (FR) | 2011-10-13 | — | — | US | disclosed |
| US-20100120856-A1 | Derivatives of the Aminated Hydroxyquinoline Class For Treating Cancers | BIOPHARMED (FR) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120856-A1 | Derivatives of the Aminated Hydroxyquinoline Class For Treating Cancers | HNMT, HRAS, NNMT | MAPT 4410/4885KDM4E 1395/4885L3MBTL1 1433/4885 |
| US-20130102630-A1 | Derivatives of the Aminated Hydroxyquinoline Class For Treating Cancers | HNMT, NQO1, NQO2 | MAPT 4538/4885KDM4E 1779/4885L3MBTL1 1835/4885 |
| US-20110251238-A1 | PPAR AGONIST COMPOSITIONS AND METHODS OF USE | PPARA, PPARG, PPARD | MAPT 4323/4885KDM4E 4239/4885L3MBTL1 4433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.