Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | KIF5B | P33176 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25284382 | 0.87 | HPGD (0.51) | NPC1NCOA1NCOA3GAAEGFR | |
| SCHEMBL25283961 | 0.86 | EGFR (0.48) | GAAPOLBEGFRKDRERBB3 | |
| SCHEMBL25293421 | 0.84 | GAA (0.53) | NPC1GAAPOLBEGFRERBB3 | |
| SCHEMBL25242828 | 0.83 | LRRK2 (0.47) | GAAPOLBEGFRERBB3HPGD | |
| SCHEMBL25241385 | 0.79 | TTK (0.42) | EGFRERBB3ABCB1ABCG2ABCC1 | |
| SCHEMBL25242554 | 0.79 | POLB (0.47) | GAAPOLBEGFRERBB3KMT2A | |
| SCHEMBL25239490 | 0.79 | LRRK2 (0.52) | TTK | |
| SCHEMBL25289693 | 0.79 | S1PR1 (0.39) | NPC1MAPTKDM4ETTK | |
| SCHEMBL25288507 | 0.78 | POLB (0.46) | NPC1GAAPOLBEGFRERBB3 | |
| SCHEMBL25245407 | 0.77 | GRM5 (0.41) | NPC1GAAPOLBEGFRERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | disclosed |