Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25283961 | 0.87 | EGFR (0.48) | HPGDEGFRERBB3GAAMAPT | |
| SCHEMBL25238174 | 0.87 | NPC1 (0.44) | HPGDEGFRERBB3ABCB1ABCG2 | |
| SCHEMBL25293421 | 0.85 | GAA (0.53) | HPGDEGFRERBB3GAAMEN1 | |
| SCHEMBL25242828 | 0.84 | LRRK2 (0.47) | HPGDEGFRERBB3ABCB1ABCG2 | |
| SCHEMBL25241385 | 0.80 | TTK (0.42) | EGFRERBB3ABCB1ABCG2 | |
| SCHEMBL25242554 | 0.80 | POLB (0.47) | EGFRERBB3GAAMEN1KMT2A | |
| SCHEMBL25287907 | 0.80 | TTK (0.42) | EGFRGABRG2GABRB3GABRA5 | |
| SCHEMBL25239490 | 0.80 | LRRK2 (0.52) | — | |
| SCHEMBL25242524 | 0.79 | KMT2A (0.66) | EGFRERBB3ABCB1ABCG2MEN1 | |
| SCHEMBL25245407 | 0.78 | GRM5 (0.41) | EGFRERBB3ABCB1ABCG2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | claimed |
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | disclosed |