Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 17/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25283961 | 0.86 | EGFR (0.48) | TTKEGFRERBB3JAK1TYK2 | |
| SCHEMBL25289693 | 0.83 | S1PR1 (0.39) | TTK | |
| SCHEMBL25243633 | 0.82 | TYK2 (0.47) | TTKJAK1TYK2 | |
| SCHEMBL25284382 | 0.80 | HPGD (0.51) | EGFRERBB3ABCB1ABCG2 | |
| SCHEMBL25241012 | 0.80 | PSEN1 (0.41) | TTK | |
| SCHEMBL25283977 | 0.80 | TYK2 (0.50) | JAK1TYK2 | |
| SCHEMBL25238174 | 0.79 | NPC1 (0.44) | TTKEGFRERBB3ABCB1ABCC1 | |
| SCHEMBL25242828 | 0.79 | LRRK2 (0.47) | TTKEGFRERBB3ABCB1ABCC1 | |
| SCHEMBL25287907 | 0.79 | TTK (0.42) | TTKEGFR | |
| SCHEMBL25293421 | 0.78 | GAA (0.53) | EGFRERBB3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | claimed |
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | disclosed |