Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 4/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.36 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25283961 | 0.85 | EGFR (0.48) | TTKPOLBGAAEGFRERBB3 | |
| SCHEMBL25284382 | 0.84 | HPGD (0.51) | GAAEGFRERBB3ABCG2ABCB1 | |
| SCHEMBL25238174 | 0.83 | NPC1 (0.44) | TTKPOLBGAAEGFRERBB3 | |
| SCHEMBL25293421 | 0.81 | GAA (0.53) | POLBGAAEGFRERBB3HPGD | |
| SCHEMBL25241012 | 0.80 | PSEN1 (0.41) | LRRK2TTK | |
| SCHEMBL25241385 | 0.79 | TTK (0.42) | TTKEGFRERBB3ABCG2ABCB1 | |
| SCHEMBL25287175 | 0.77 | POLB (0.49) | THRBPOLBGAAABL1AKR1C3 | |
| SCHEMBL25288626 | 0.77 | TYK2 (0.45) | THRBSCN9APOLBGAAEGFR | |
| SCHEMBL25242554 | 0.76 | POLB (0.47) | POLBGAAEGFRERBB3 | |
| SCHEMBL25245407 | 0.74 | GRM5 (0.41) | POLBGAAEGFRERBB3ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | claimed |
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | disclosed |